The global bone regeneration market is set to witness a valuation of US$ 5,380.75 million in 2023, and further expand at a CAGR of 3.8% to reach US$ 7,827.8 million by 2033. In terms of product type, bone graft substitutes led the market with a share of 81.2% in 2022.
The need for reconstructive surgery coupled with the prevalence of bone diseases across the globe has improved the demand for bone regenerative techniques. Statistics show that nearly 10% of men and 18% of women above 60 years have symptomatic osteoarthritis. Apart from this, a massive spike in bone injuries and hip fractures, especially among sports enthusiasts, has resulted in increased demand for bone regeneration surgeries.
Alternatives to bone grafts are used to cure delayed fracture unions, fuse the spine, repair bone abnormalities, and fill cavities brought on by a variety of factors. The substance is derived from a range of sources, including synthetics, bone void fillers, bone morphogenetic proteins, demineralized bone matrix, autografts, allografts, and others.
Globally, pediatric deformity, degenerative diseases, musculoskeletal oncology, spinal deformity, and cases of trauma and injury comprise the bulk of orthopedic problems. These problems are especially noticeable in developing economies such as India, China, and Brazil.
The market for bone regeneration is hence predicted to expand as more people develop musculoskeletal problems or disorders. The global market is expected to grow at a CAGR of 3.8% over the forecast period.
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Degenerative joint illnesses are becoming more common, which is aiding the growth of the industry. In the absence of treatment for the illness, numerous osteoarthritis patients develop extensive joint deterioration. Surgery utilizing bone replacements and transplants is essential to halt osteoarthritis-related progressive joint degeneration. Improvements in biomaterial and tissue engineering, according to the American College of Rheumatology, create new opportunities for incorporating surgical techniques in osteoarthritis.
According to healthcare professionals, the body's natural bone-healing mechanisms are aided by low-level electrical fields. Currently, this application is using the same technology. Researchers are leveraging advanced healthcare technologies to make additional strides, such as developing new strategies for promoting bone regeneration or making enhancements to the current devices.
Further, with a growing number of knee surgeries, healthcare professionals are developing advanced procedures and techniques to make the procedure less invasive and to increase the healing time. As per the American Academy of Orthopaedic Surgeons, over 6 million have undergone total knee arthroplasty in 2010 and the number has risen dramatically over the past decade.
For instance, in August 2022, OSSIO Inc., a leading orthopedic fixation technology company announced the launch and first commercial use of OSSIOfiber suture anchors in the USA This is accessible and can be used as bio-integrative implants in foot/ankle, and knee, shoulder, and elbow surgery.
Patients with non-union or delayed union of a bone fracture are usually advised to try traditional physiotherapy, yoga, or Ayurveda treatments. Several reviews on the therapy of fractures have incorrectly classed electrical and ultrasonic treatment as contraindications. Chiropractors represent a huge threat to the industry's ability to continue running as they are the leading alternative medical profession. The emergence of more potent alternative therapies hinder the growth of the bone regeneration industry.
Even though various research is being carried out to evaluate the efficacy of bone growth stimulator devices, the amount of scientific data currently accessible is insufficient to address their magnitude. According to an IJO review, it is challenging to do meta-analyses on the effectiveness of bone growth stimulator devices due to the variability of the clinical study designs for such devices.
With robust research and development, numerous research programs are attempting to solve device-related constraints. However, there are several shortcomings with the various devices on the market, and they must adhere to strict rules set forth by the regulatory bodies of distinct nations. The device is inadequate in several areas, including the shelf life and biocompatibility of the materials.
| Attributes | Details |
|---|---|
| Bone Regeneration Market CAGR (2023 to 2033) | 3.8% |
| Bone Regeneration Market Size (2023) | US$ 5,380.75 million |
| Bone Regeneration Market Size (2033) | US$ 7,827.8 million |
Principal Consultant
As per Future Market Insights (FMI), the bone regeneration market held approximately 13.3% of the overall US$ 37,200 million global orthopedics market in 2021. The bone regeneration industry expanded at a CAGR of 2.4% from 2018 to 2022 due to the increasing incidence of bone fractures and delayed bone healing.
Fractures are treated using a variety of techniques, such as surgery, amputations, allografts, and synthetic bone grafts. Low-intensity ultrasound stimulation and electrical bone growth stimulation are two examples of non-invasive treatments.
These devices speed up the healing process and are approved by regulatory authorities such as the United States Food and Drug Administration (FDA). Additionally, the reimbursement guidelines for bone growth stimulators have been updated by CMS and Medicare. Higher adoption rates of non-invasive techniques have also resulted in cost-effective methods, promoting the adoption of bone regenerative techniques.
Hence, players are introducing advanced products and technological innovations to leverage untapped market opportunities. Top manufacturers of bone regenerations products are expanding the value chain to integrate into the market of developing economies.
The increasing prevalence of patients with one or more comorbidities, such as degenerative joint diseases, osteoporosis, osteoarthritis, etc., make the bones brittle and susceptible to fractures and delayed healing. This is expected to be a prominent driver of the global bone regeneration sector in the coming years.
| Country | Market Share (2022) |
|---|---|
| United States | 25.5% |
| Germany | 8.6% |
| Japan | 3.3% |
The USA dominated the North American market with a total share of about 73.7% in 2021 and is expected to experience the same growth over the forecast period. The USA is considered to be the most attractive market due to the increased prevalence of joint illnesses, resulting in an increase in surgical treatments. The market for bone regeneration is expanding as a result of significant investment in Research and Development activities and the introduction of new products in the area.
According to the American Academy of Orthopedic Surgeons, in the USA by 2030, the number of total knee arthroplasty surgeries is expected to reach 3 million. Around 4.3 million spinal fusions are performed in the United States every year. This is expected to create lucrative growth prospects in the United States bone regeneration business over the upcoming decade.
Germany is set to exhibit a CAGR of nearly 3.7% in the Europe market during the forecast period. Growth is primarily underpinned by increasingly available customized bone grafts and substitute treatments.
In Germany, 17.9% of adults over 18 reported having osteoarthritis, with women experiencing a higher frequency (21.8%) than men (13.9%), according to 2017 data from The Journal of Health Monitoring. On the other hand, favorable reimbursement policies provided by organizations are pushing patients to opt for cost-effective bone regenerative treatments, fueling growth in the market.
China held a 50.3% share in the East Asia bone regeneration market in 2022 and is projected to increase at a CAGR rate of 4.6% during the forecast period. With the developing healthcare system in China, healthcare professionals are witnessing a paradigm shift in regenerative medicine technology.
The advent of 3D structures and non-invasive bone grafting procedures has transformed the face of China's bone regeneration market. Further, with the growing prevalence of bone disorders, even in children and adolescents has led to an uptake in bone regenerative product sales. Backed by these factors, the demand in China is expected to surge over the forecast period.
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Bone graft substitutes project lucrative growth at a CAGR of 4.1% during the forecast period, and led the market with a share of around 81.2% in 2022. Bone graft substitutes are used to repair delayed fracture unions, fuse the spine, fill voids caused by a variety of conditions, and bridge bone abnormalities. The bone graft substitute has a high likelihood of successful bone fusion making it the most profitable product available on the market for bone regeneration.
Trauma cases held a revenue share of 22.8% in 2022 and are expected to increase at a CAGR of 2.6% by 2033. The leading cause of death for those under the age of 65 is trauma. Additionally, injury-related mortality is a significant global public health burden, driving the market. Emergency rooms are a sensitive indicator of the impact generated by traumatic injury. The market is anticipated to grow between 2023 and 2033 as bone graft substitute plays a significant role in trauma cases.
Due to the availability of products and therapies for treating joint problems, hospitals currently hold the top position in the bone regeneration market with a 49.1% market share. Throughout the forecast period, they are expected to maintain this position while growing at a CAGR of 3.6%. As more patients are admitted to hospitals for the treatment of musculoskeletal injuries and diseases, the market for bone regeneration is anticipated to expand.
Growth in the market is facilitated by the availability of cutting-edge medical equipment with better efficiency and technology, as well as by qualified personnel and healthcare experts. Numerous patients are drawn to hospitals because of the existence of cutting-edge medical technology to receive treatment and experience the most satisfaction and comfort. As a result, hospitals dominate the market for bone regeneration compared to other end users.
Key competitors in the bone regeneration sector are focusing on collaborations, product launches, and expansion to achieve a dominant position in the market. With the use of these strategies, market participants can increase the number of products they offer and their market penetration. As a result, they have seen a rise in their overall revenue share in the global market for bone regeneration.
Given below are a few examples of the key strategies followed by the manufacturers:
Key Players
The bone regeneration market CAGR for 2033 is 3.8%.
The market is estimated to reach US$ 7,827.8 million by 2033.
North America, Europe, and Asia-Pacific are the top 3 countries leading the market.
The market is estimated to secure a valuation of US$ 5,380.75 million in 2023.
India, Japan, and China dominate the Asian market.
1. Executive Summary 1.1. Global Market Outlook 1.2. Demand-side Trends 1.3. Supply-side Trends 1.4. Technology Roadmap Analysis 1.5. Analysis and Recommendations 2. Market Overview 2.1. Market Coverage / Taxonomy 2.2. Market Definition / Scope / Limitations 3. Market Background 3.1. Market Dynamics 3.1.1. Drivers 3.1.2. Restraints 3.1.3. Opportunity 3.1.4. Trends 3.2. Scenario Forecast 3.2.1. Demand in Optimistic Scenario 3.2.2. Demand in Likely Scenario 3.2.3. Demand in Conservative Scenario 3.3. Opportunity Map Analysis 3.4. Investment Feasibility Matrix 3.5. PESTLE and Porter’s Analysis 3.6. Regulatory Landscape 3.6.1. By Key Regions 3.6.2. By Key Countries 3.7. Regional Parent Market Outlook 4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033 4.1. Historical Market Size Value (US$ Million) Analysis, 2018 to 2022 4.2. Current and Future Market Size Value (US$ Million) Projections, 2023 to 2033 4.2.1. Y-o-Y Growth Trend Analysis 4.2.2. Absolute $ Opportunity Analysis 5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Product 5.1. Introduction / Key Findings 5.2. Historical Market Size Value (US$ Million) Analysis By Product, 2018 to 2022 5.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Product, 2023 to 2033 5.3.1. Demineralized Bone Matrix(DBM) 5.3.2. Xenograft 5.3.3. Autografts 5.3.4. Synthetic Bone Graft 5.3.5. Bone Morphogenetic Protein(BMP) 5.3.6. Non-Invasive Electrical Bone Growth Stimulators 5.3.7. Invasive Electrical Bone Growth Stimulators 5.4. Y-o-Y Growth Trend Analysis By Product, 2018 to 2022 5.5. Absolute $ Opportunity Analysis By Product, 2023 to 2033 6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Application 6.1. Introduction / Key Findings 6.2. Historical Market Size Value (US$ Million) Analysis By Application, 2018 to 2022 6.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Application, 2023 to 2033 6.3.1. Osteoarthritis (OA) 6.3.2. Osteoporosis 6.3.3. Rheumatoid Arthritis (RA) 6.3.4. Spinal Disorders 6.3.5. Dentistry 6.3.6. Craniomaxillofacial (CMF) 6.3.7. Trauma Cases 6.4. Y-o-Y Growth Trend Analysis By Application, 2018 to 2022 6.5. Absolute $ Opportunity Analysis By Application, 2023 to 2033 7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Age Group 7.1. Introduction / Key Findings 7.2. Historical Market Size Value (US$ Million) Analysis By Age Group, 2018 to 2022 7.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By Age Group, 2023 to 2033 7.3.1. Pediatric 7.3.2. Adults 7.3.3. Geriatric 7.4. Y-o-Y Growth Trend Analysis By Age Group, 2018 to 2022 7.5. Absolute $ Opportunity Analysis By Age Group, 2023 to 2033 8. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By End User 8.1. Introduction / Key Findings 8.2. Historical Market Size Value (US$ Million) Analysis By End User, 2018 to 2022 8.3. Current and Future Market Size Value (US$ Million) Analysis and Forecast By End User, 2023 to 2033 8.3.1. Hospitals 8.3.2. Orthopedic Clinics 8.3.3. Ambulatory Surgical Centers 8.4. Y-o-Y Growth Trend Analysis By End User, 2018 to 2022 8.5. Absolute $ Opportunity Analysis By End User, 2023 to 2033 9. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region 9.1. Introduction 9.2. Historical Market Size Value (US$ Million) Analysis By Region, 2018 to 2022 9.3. Current Market Size Value (US$ Million) Analysis and Forecast By Region, 2023 to 2033 9.3.1. North America 9.3.2. Latin America 9.3.3. Western Europe 9.3.4. Eastern Europe 9.3.5. South Asia and Pacific 9.3.6. East Asia 9.3.7. Middle East and Africa 9.4. Market Attractiveness Analysis By Region 10. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 10.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 10.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 10.2.1. By Country 10.2.1.1. USA 10.2.1.2. Canada 10.2.2. By Product 10.2.3. By Application 10.2.4. By Age Group 10.2.5. By End User 10.3. Market Attractiveness Analysis 10.3.1. By Country 10.3.2. By Product 10.3.3. By Application 10.3.4. By Age Group 10.3.5. By End User 10.4. Key Takeaways 11. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 11.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 11.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 11.2.1. By Country 11.2.1.1. Brazil 11.2.1.2. Mexico 11.2.1.3. Rest of Latin America 11.2.2. By Product 11.2.3. By Application 11.2.4. By Age Group 11.2.5. By End User 11.3. Market Attractiveness Analysis 11.3.1. By Country 11.3.2. By Product 11.3.3. By Application 11.3.4. By Age Group 11.3.5. By End User 11.4. Key Takeaways 12. Western Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 12.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 12.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 12.2.1. By Country 12.2.1.1. Germany 12.2.1.2. UK 12.2.1.3. France 12.2.1.4. Spain 12.2.1.5. Italy 12.2.1.6. Rest of Western Europe 12.2.2. By Product 12.2.3. By Application 12.2.4. By Age Group 12.2.5. By End User 12.3. Market Attractiveness Analysis 12.3.1. By Country 12.3.2. By Product 12.3.3. By Application 12.3.4. By Age Group 12.3.5. By End User 12.4. Key Takeaways 13. Eastern Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 13.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 13.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 13.2.1. By Country 13.2.1.1. Poland 13.2.1.2. Russia 13.2.1.3. Czech Republic 13.2.1.4. Romania 13.2.1.5. Rest of Eastern Europe 13.2.2. By Product 13.2.3. By Application 13.2.4. By Age Group 13.2.5. By End User 13.3. Market Attractiveness Analysis 13.3.1. By Country 13.3.2. By Product 13.3.3. By Application 13.3.4. By Age Group 13.3.5. By End User 13.4. Key Takeaways 14. South Asia and Pacific Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 14.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 14.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 14.2.1. By Country 14.2.1.1. India 14.2.1.2. Bangladesh 14.2.1.3. Australia 14.2.1.4. New Zealand 14.2.1.5. Rest of South Asia and Pacific 14.2.2. By Product 14.2.3. By Application 14.2.4. By Age Group 14.2.5. By End User 14.3. Market Attractiveness Analysis 14.3.1. By Country 14.3.2. By Product 14.3.3. By Application 14.3.4. By Age Group 14.3.5. By End User 14.4. Key Takeaways 15. East Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 15.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 15.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 15.2.1. By Country 15.2.1.1. China 15.2.1.2. Japan 15.2.1.3. South Korea 15.2.2. By Product 15.2.3. By Application 15.2.4. By Age Group 15.2.5. By End User 15.3. Market Attractiveness Analysis 15.3.1. By Country 15.3.2. By Product 15.3.3. By Application 15.3.4. By Age Group 15.3.5. By End User 15.4. Key Takeaways 16. Middle East and Africa Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country 16.1. Historical Market Size Value (US$ Million) Trend Analysis By Market Taxonomy, 2018 to 2022 16.2. Market Size Value (US$ Million) Forecast By Market Taxonomy, 2023 to 2033 16.2.1. By Country 16.2.1.1. GCC Countries 16.2.1.2. South Africa 16.2.1.3. Israel 16.2.1.4. Rest of MEA 16.2.2. By Product 16.2.3. By Application 16.2.4. By Age Group 16.2.5. By End User 16.3. Market Attractiveness Analysis 16.3.1. By Country 16.3.2. By Product 16.3.3. By Application 16.3.4. By Age Group 16.3.5. By End User 16.4. Key Takeaways 17. Key Countries Market Analysis 17.1. USA 17.1.1. Pricing Analysis 17.1.2. Market Share Analysis, 2022 17.1.2.1. By Product 17.1.2.2. By Application 17.1.2.3. By Age Group 17.1.2.4. By End User 17.2. Canada 17.2.1. Pricing Analysis 17.2.2. Market Share Analysis, 2022 17.2.2.1. By Product 17.2.2.2. By Application 17.2.2.3. By Age Group 17.2.2.4. By End User 17.3. Brazil 17.3.1. Pricing Analysis 17.3.2. Market Share Analysis, 2022 17.3.2.1. By Product 17.3.2.2. By Application 17.3.2.3. By Age Group 17.3.2.4. By End User 17.4. Mexico 17.4.1. Pricing Analysis 17.4.2. Market Share Analysis, 2022 17.4.2.1. By Product 17.4.2.2. By Application 17.4.2.3. By Age Group 17.4.2.4. By End User 17.5. Germany 17.5.1. Pricing Analysis 17.5.2. Market Share Analysis, 2022 17.5.2.1. By Product 17.5.2.2. By Application 17.5.2.3. By Age Group 17.5.2.4. By End User 17.6. UK 17.6.1. Pricing Analysis 17.6.2. Market Share Analysis, 2022 17.6.2.1. By Product 17.6.2.2. By Application 17.6.2.3. By Age Group 17.6.2.4. By End User 17.7. France 17.7.1. Pricing Analysis 17.7.2. Market Share Analysis, 2022 17.7.2.1. By Product 17.7.2.2. By Application 17.7.2.3. By Age Group 17.7.2.4. By End User 17.8. Spain 17.8.1. Pricing Analysis 17.8.2. Market Share Analysis, 2022 17.8.2.1. By Product 17.8.2.2. By Application 17.8.2.3. By Age Group 17.8.2.4. By End User 17.9. Italy 17.9.1. Pricing Analysis 17.9.2. Market Share Analysis, 2022 17.9.2.1. By Product 17.9.2.2. By Application 17.9.2.3. By Age Group 17.9.2.4. By End User 17.10. Poland 17.10.1. Pricing Analysis 17.10.2. Market Share Analysis, 2022 17.10.2.1. By Product 17.10.2.2. By Application 17.10.2.3. By Age Group 17.10.2.4. By End User 17.11. Russia 17.11.1. Pricing Analysis 17.11.2. Market Share Analysis, 2022 17.11.2.1. By Product 17.11.2.2. By Application 17.11.2.3. By Age Group 17.11.2.4. By End User 17.12. Czech Republic 17.12.1. Pricing Analysis 17.12.2. Market Share Analysis, 2022 17.12.2.1. By Product 17.12.2.2. By Application 17.12.2.3. By Age Group 17.12.2.4. By End User 17.13. Romania 17.13.1. Pricing Analysis 17.13.2. Market Share Analysis, 2022 17.13.2.1. By Product 17.13.2.2. By Application 17.13.2.3. By Age Group 17.13.2.4. By End User 17.14. India 17.14.1. Pricing Analysis 17.14.2. Market Share Analysis, 2022 17.14.2.1. By Product 17.14.2.2. By Application 17.14.2.3. By Age Group 17.14.2.4. By End User 17.15. Bangladesh 17.15.1. Pricing Analysis 17.15.2. Market Share Analysis, 2022 17.15.2.1. By Product 17.15.2.2. By Application 17.15.2.3. By Age Group 17.15.2.4. By End User 17.16. Australia 17.16.1. Pricing Analysis 17.16.2. Market Share Analysis, 2022 17.16.2.1. By Product 17.16.2.2. By Application 17.16.2.3. By Age Group 17.16.2.4. By End User 17.17. New Zealand 17.17.1. Pricing Analysis 17.17.2. Market Share Analysis, 2022 17.17.2.1. By Product 17.17.2.2. By Application 17.17.2.3. By Age Group 17.17.2.4. By End User 17.18. China 17.18.1. Pricing Analysis 17.18.2. Market Share Analysis, 2022 17.18.2.1. By Product 17.18.2.2. By Application 17.18.2.3. By Age Group 17.18.2.4. By End User 17.19. Japan 17.19.1. Pricing Analysis 17.19.2. Market Share Analysis, 2022 17.19.2.1. By Product 17.19.2.2. By Application 17.19.2.3. By Age Group 17.19.2.4. By End User 17.20. South Korea 17.20.1. Pricing Analysis 17.20.2. Market Share Analysis, 2022 17.20.2.1. By Product 17.20.2.2. By Application 17.20.2.3. By Age Group 17.20.2.4. By End User 17.21. GCC Countries 17.21.1. Pricing Analysis 17.21.2. Market Share Analysis, 2022 17.21.2.1. By Product 17.21.2.2. By Application 17.21.2.3. By Age Group 17.21.2.4. By End User 17.22. South Africa 17.22.1. Pricing Analysis 17.22.2. Market Share Analysis, 2022 17.22.2.1. By Product 17.22.2.2. By Application 17.22.2.3. By Age Group 17.22.2.4. By End User 17.23. Israel 17.23.1. Pricing Analysis 17.23.2. Market Share Analysis, 2022 17.23.2.1. By Product 17.23.2.2. By Application 17.23.2.3. By Age Group 17.23.2.4. By End User 18. Market Structure Analysis 18.1. Competition Dashboard 18.2. Competition Benchmarking 18.3. Market Share Analysis of Top Players 18.3.1. By Regional 18.3.2. By Product 18.3.3. By Application 18.3.4. By Age Group 18.3.5. By End User 19. Competition Analysis 19.1. Competition Deep Dive 19.1.1. Medtronic plc. 19.1.1.1. Overview 19.1.1.2. Product Portfolio 19.1.1.3. Profitability by Market Segments 19.1.1.4. Sales Footprint 19.1.1.5. Strategy Overview 19.1.1.5.1. Marketing Strategy 19.1.2. Stryker Corporation 19.1.2.1. Overview 19.1.2.2. Product Portfolio 19.1.2.3. Profitability by Market Segments 19.1.2.4. Sales Footprint 19.1.2.5. Strategy Overview 19.1.2.5.1. Marketing Strategy 19.1.3. DePuy Synthes Inc. 19.1.3.1. Overview 19.1.3.2. Product Portfolio 19.1.3.3. Profitability by Market Segments 19.1.3.4. Sales Footprint 19.1.3.5. Strategy Overview 19.1.3.5.1. Marketing Strategy 19.1.4. Integra Lifesciences Holdings Corporation 19.1.4.1. Overview 19.1.4.2. Product Portfolio 19.1.4.3. Profitability by Market Segments 19.1.4.4. Sales Footprint 19.1.4.5. Strategy Overview 19.1.4.5.1. Marketing Strategy 19.1.5. Zimmer Biomet HoldingsInc. 19.1.5.1. Overview 19.1.5.2. Product Portfolio 19.1.5.3. Profitability by Market Segments 19.1.5.4. Sales Footprint 19.1.5.5. Strategy Overview 19.1.5.5.1. Marketing Strategy 19.1.6. Xtant Medical HoldingsInc. 19.1.6.1. Overview 19.1.6.2. Product Portfolio 19.1.6.3. Profitability by Market Segments 19.1.6.4. Sales Footprint 19.1.6.5. Strategy Overview 19.1.6.5.1. Marketing Strategy 19.1.7. ArthrexInc. 19.1.7.1. Overview 19.1.7.2. Product Portfolio 19.1.7.3. Profitability by Market Segments 19.1.7.4. Sales Footprint 19.1.7.5. Strategy Overview 19.1.7.5.1. Marketing Strategy 19.1.8. Baxter International Inc. 19.1.8.1. Overview 19.1.8.2. Product Portfolio 19.1.8.3. Profitability by Market Segments 19.1.8.4. Sales Footprint 19.1.8.5. Strategy Overview 19.1.8.5.1. Marketing Strategy 19.1.9. Musculoskeletal Transplant Foundation 19.1.9.1. Overview 19.1.9.2. Product Portfolio 19.1.9.3. Profitability by Market Segments 19.1.9.4. Sales Footprint 19.1.9.5. Strategy Overview 19.1.9.5.1. Marketing Strategy 19.1.10. Smith & NephewInc. 19.1.10.1. Overview 19.1.10.2. Product Portfolio 19.1.10.3. Profitability by Market Segments 19.1.10.4. Sales Footprint 19.1.10.5. Strategy Overview 19.1.10.5.1. Marketing Strategy 19.1.11. Orthofix HoldingsInc. 19.1.11.1. Overview 19.1.11.2. Product Portfolio 19.1.11.3. Profitability by Market Segments 19.1.11.4. Sales Footprint 19.1.11.5. Strategy Overview 19.1.11.5.1. Marketing Strategy 19.1.12. NuvasiveInc. 19.1.12.1. Overview 19.1.12.2. Product Portfolio 19.1.12.3. Profitability by Market Segments 19.1.12.4. Sales Footprint 19.1.12.5. Strategy Overview 19.1.12.5.1. Marketing Strategy 19.1.13. Allosaurus 19.1.13.1. Overview 19.1.13.2. Product Portfolio 19.1.13.3. Profitability by Market Segments 19.1.13.4. Sales Footprint 19.1.13.5. Strategy Overview 19.1.13.5.1. Marketing Strategy 19.1.14. NovaBone ProductsLLC 19.1.14.1. Overview 19.1.14.2. Product Portfolio 19.1.14.3. Profitability by Market Segments 19.1.14.4. Sales Footprint 19.1.14.5. Strategy Overview 19.1.14.5.1. Marketing Strategy 19.1.15. BonAlive Biomaterials Ltd. 19.1.15.1. Overview 19.1.15.2. Product Portfolio 19.1.15.3. Profitability by Market Segments 19.1.15.4. Sales Footprint 19.1.15.5. Strategy Overview 19.1.15.5.1. Marketing Strategy 19.1.16. Sigma Graft Biomaterials 19.1.16.1. Overview 19.1.16.2. Product Portfolio 19.1.16.3. Profitability by Market Segments 19.1.16.4. Sales Footprint 19.1.16.5. Strategy Overview 19.1.16.5.1. Marketing Strategy 19.1.17. RTI Surgical 19.1.17.1. Overview 19.1.17.2. Product Portfolio 19.1.17.3. Profitability by Market Segments 19.1.17.4. Sales Footprint 19.1.17.5. Strategy Overview 19.1.17.5.1. Marketing Strategy 19.1.18. Institut Straumann AG 19.1.18.1. Overview 19.1.18.2. Product Portfolio 19.1.18.3. Profitability by Market Segments 19.1.18.4. Sales Footprint 19.1.18.5. Strategy Overview 19.1.18.5.1. Marketing Strategy 19.1.19. ExactechInc 19.1.19.1. Overview 19.1.19.2. Product Portfolio 19.1.19.3. Profitability by Market Segments 19.1.19.4. Sales Footprint 19.1.19.5. Strategy Overview 19.1.19.5.1. Marketing Strategy 19.1.20. A.B. Dental Devices Ltd 19.1.20.1. Overview 19.1.20.2. Product Portfolio 19.1.20.3. Profitability by Market Segments 19.1.20.4. Sales Footprint 19.1.20.5. Strategy Overview 19.1.20.5.1. Marketing Strategy 20. Assumptions & Acronyms Used 21. Research Methodology
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