An Incisive, In-depth Analysis on the Protein A Resins Market
This study offers a comprehensive, 360 degree analysis on the Protein A Resins market, bringing to fore insights that can help stakeholders identify the opportunities as well as challenges. It tracks the global Protein A Resins market across key regions, and offers in-depth commentary and accurate quantitative insights. The study also includes incisive competitive landscape analysis, and provides key recommendations to market players on winning imperatives and successful strategies.
Protein A Resin Market Outlook & Key Findings
- Protein A resin market expected to grow at a CAGR of 8.2% through 2030
- Growing research in monoclonal antibodies and biosimilars driving the market
- Agarose-based matrix to contribute the largest market share due to greater binding specificity
- North America, led by the US, currently accounts for more than 70% of revenue share
Engineered Synthesis to Propel the Protein A Resin Market
Synthetic biology has been garnering the interest of scientists and researchers. The biopharmaceutical industry is emphasizing on usage of protein-engineered products for developing protein-based drugs.
Demand for mAb (monoclonal antibodies) for treating chronic diseases effectively will also bolster the market, especially after launch of MabSelect PrismA by GE Healthcare in Sep 2017. This cost-effective product makes use of a novel agarose bead and Protein A ligand for achieving DBCs (dynamic binding capacities).
At the same time, Teva introduced new CIP and SIP strategy for regenerating and cleaning MabSelect SuRe chromatography resin to improve lifespan of Protein A.
However, this synthesis of proteins is quite cumbersome.
MIT chemists have come up with their tabletop automated flow synthesis machine for dramatically reducing the time needed for generating synthetic proteins.
The machine can thus string loads of amino acids together within a few hours. This automation is likely to encourage the entry of new players, as time and cost – both would be minimized and the protein A resin market would get a boost in the forecast period.
Protein A Resin Industry Players Focusing on Launching Innovative Products
The protein A resin market players are on the “innovation” and “approval” spree with regards to manufacturing biotherapeutics, so as to have an edge over their counterparts. These innovations and approvals are expected to help the protein A resin market in the good stead in the years to come.
For instance, Avantor, in Mar 2020, launched new protein A chromatography resin – PROchievA – that renders supply chain flexibility along with improvement in monoclonal antibodies’ (mAbs) production’s downstream purification process.
Purolite Ltd., in Nov 2019, asserted that FDA-approved biotherapeutics could be manufactured using its Praesto agarose-based chromatography resin range. The ailments addressed include diabetes, dementia, rheumatoid arthritis, and cancer. Prior to that, in Sep 2018, Purolite opened Protein A resin plant in Wales, which has the capability of producing 100,000L of Praesto range of resins.
In Aug 2019, Praesto Jetted A50 was the very first protein A resin to function as per Purolite’s patented technology, i.e. “Jetting”.
In Nov 2019, TriAltus Bioscience LLC launched its Activated lm7 affinity chromatography resin to cater to CL7/lm7 protein purification system. Its binding capacity is more than twice the original binding capacity of single-step protein purification system (from 15-20 mg/ml to 35-40 mg/ml).
Protein A Resin Market Trends
The demand for purification with respect to immunotherapies is one of the trends catching up. For instance - US FDA, of late, approved immunotherapy to treat CD19 positive hematological cancers. Likewise, protein A affinity chromatography is used to purify FGFR4 that is targeted in CAR-T therapy by chimeric antigen receptors.
As far as matrices are concerned, the agarose-based matrix holds the distinction of having a higher gelling strength with anti-convection medium to facilitate gel electrophoresis. That’s why, agarose-based matrix is used in molecular biology to separate large molecules (DNA, in particular).
On the other hand, mixed-mode chromatography is emerging as one of the most viable purification methods for biomolecules that are, otherwise, difficult to purify through conventional chromatography platforms. Though in its nascent stage, mixed-mode chromatography is likely to fulfil the following objectives in the forecast period:
- Improved activity and yield
- Higher resolution in comparison with unimodal interactions
- Minimal feed manipulation before binding
- Large design space to facilitate protein interaction
Protein A Resin: Regional Analysis
- North America holds the largest share of protein A resin market. This could be attributed to massive production coupled with clinical trials regarding biologics inclusive of monoclonal antibodies
- Europe and Latin America are the other lucrative markets with increase in discovery of the biological entities that are likely to upscale the adoption of these protein A resins in the forecast period. Plus, rising investments in protein-based research are expected to augment the market in these regions
- Asia Pacific is witnessing a growing demand for immunotherapy drugs to treat chronic ailments. This factor is likely to place it at a formidable position in the forecast period
In all, natural protein contributes for the highest market share followed by recombinant protein
Key Players in the Protein A Resin Market
The protein A resin market players are launching new products to address cancer, microbial infections, immune therapy, and cardiovascular ailments. For instance – Novasep has come up with AbSolute High Cap product in order to capture polyclonal as well as monoclonal antibodies from large samples. Their purification needs protein A resin.
The other mode of growth followed by the companies includes extensive in-house production. For instance – Thermo Fisher’s POROS MabCapture A Select (MCAS) is available at lower price, so as to cut down on cost of clinical manufacturing. The third mode is “expansion”. For instance – In Jun 2020, Avantor, Inc. announced expansion of its innovation center to enhance its bioprocessing efficiency.
The other players in the protein A resin market include:
- Expedeon Ltd.
- Agilent Technologies Inc.
- Bio-Rad Laboratories Inc.
- Merck KGaA
- EMD Millipore
Protein A Resin Market: The Way Forward
Substantial research is being conducted pertaining to monoclonal antibodies. Innovations resulting out of this research is expected to gain traction in the forecast period.
As per FMI’s analysis, the protein A resin market is expected to witness a growth rate of 8.2% Y-oY, with North America and Europe holding substantial share of the market.
Organizations with innovative work capabilities and adoption to technological advancements will be in place to sustain themselves in protein A resin market.
A recent market study published by Future Market Insights (FMI) on the protein A resin market including global industry analysis for 2015-2019 & opportunity assessment for 2020-2030 delivers a comprehensive assessment of the most important market dynamics. After conducting a thorough research on the historical as well as current growth parameters of the market, growth prospects are obtained with utmost precision.
Protein A Resin Market: Segmentation
The global protein A resin is segmented in detail to cover every aspect of the market and present a complete market intelligence approach to the reader.
Chapter 01 – Executive Summary
The report initiates with the executive summary of the protein A resin market, which includes a snapshot of key findings and statistics. It also includes market size and revenue distribution of the market.
Chapter 02 – Market Overview
Readers can find the definition and a detailed segmentation of the protein A resin market in this chapter, which will help them understand the basics of the market.
Chapter 03 – Key Market Trends
This chapter highlights the key trends impacting the growth of the protein A resin market over the forecast period. This chapter helps reader to understand both - supply side and demand side trends of the market.
Chapter 04 – Market Context
This section includes premium insights such as product adoption analysis, application road map, key promotional strategies, regulations, and many more. It helps readers understand the key factors associated with the protein A resin market.
Chapter 05 – Market Background
This chapter explains the macroeconomic factors, drivers, restraints, and opportunities’ along with current COVID-19 impact that are expected to influence growth of the protein A resin market over the forecast period. Moreover, in-depth information about the market dynamics and their impact on the market have been provided in the successive section.
Chapter 06 – Global Protein A Resin Market - Pricing Analysis
This section highlights the market pricing analysis by equipment type. It helps reader understand the pricing variation of the market in various geographies.
Chapter 07 – Global Protein A Resin Value Analysis 2015-2019 & Opportunity Assessment 2020-2030
This section gives the global market value analysis and forecast for the protein A resin during the forecast period. It includes a detailed analysis of the historical protein A resin market, along with an opportunity analysis for the future. Readers can also find the absolute $ opportunity for the current year (2020), and an incremental $ opportunity for the forecast period (2020–2030).
Chapter 08 – Global Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030, by Product Type
Based on product type, the protein A resin market is segmented into natural protein A resin and recombinant protein A resin. In this chapter, readers can find the key trends and developments in protein A resin and market attractiveness based on product type.
Chapter 09 – Global Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030, by Matrix Type
This chapter provides details about the protein A resin based on matrix type, and has been classified into agarose based matrix, glass or silica based ECG, organic polymer based. Herein, readers can understand the market attractiveness based on matrix type.
Chapter 10 – Global Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030, by Application
This chapter provides details about the protein A resin based on application, and comprises immunoprecipitation and antibody purification. Readers can understand the market attractiveness based on application.
Chapter 11 – Global Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030, by End User
This chapter provides details about the market based on end user, and spans biopharmaceutical manufacturers, clinical research laboratories and academic institutes. In this chapter, readers can understand the market attractiveness analysis based on end user.
Chapter 12 – Global Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030, by Region
This chapter explains how the market will grow across various regions such as North America, Latin America, Europe, South Asia, East Asia, Oceania, and Middle East & Africa (MEA).
Chapter 13 – North America Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter gives a detailed analysis of growth of North America’s protein A resin market, along with a country-wise assessment that includes the US and Canada. Readers can also find the regional trends, and market growth based on the application and countries in North America.
Chapter 14 – Latin America Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter provides the growth scenario of the protein A resin market in Argentina, Brazil, Mexico, and the Rest of Latin America. Along with this, assessment of the market across target segments has been provided.
Chapter 15 –Europe Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter provides the growth scenario of the protein A resin market in Germany, the U.K., France, Spain, Italy, Russia, and the Rest of Europe.
Chapter 16 – South Asia Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter provides the growth scenario of the protein A resin market in South Asia in several countries such as India, Thailand, Indonesia, Malaysia, and rest of South Asia.
Chapter 17 – East Asia Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter highlights the growth of the protein A resin in East Asia by focusing on China, Japan & South Korea. This section also help readers understand the key factors that are responsible for the growth of the protein A resin market in East Asia.
Chapter 18 – Oceania Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter highlights the growth of the protein A resin in Oceania. It also helps readers understand the key factors that are responsible for the growth of the protein A resin market in Australia and New Zealand.
Chapter 19 – MEA Protein A Resin Analysis 2015-2019 & Opportunity Assessment 2020-2030
This chapter provides information about how the protein A resin market will grow in major countries in MEA such as GCC Countries, South Africa, Turkey, and the Rest of MEA during the forecast period.
Chapter 20 – Key and Emerging Countries Analysis
This section includes analysis of protein A resin market for key and emerging countries. Reader can understand the market value and volume by product type, matrix type, application, and end user for key countries.
Chapter 21 – Market Structure Analysis
This chapter highlights the tier structure analysis, market concentration analysis and company share analysis along with sales footprint analysis of key players operating in the market.
Chapter 22 – Competition Analysis
In this chapter, readers can find a comprehensive list of all the prominent stakeholders in the protein A resin market, along with a detailed information about each company, which includes company overview, revenue shares, strategic overview, and recent company developments. Some of the market players featured in the report are General Electric Company, GenScript, Novasep, Expedeon Ltd., Thermo Fisher Scientific Inc., REPLIGEN CORPORATION, Merck Millipore, Tosoh Bioscience and among others.
Chapter 23 – Assumptions and Acronyms
This chapter includes a list of acronyms and assumptions that provides a base to the information and statistics included in the protein A resin report.
Chapter 24 – Research Component Methodology
This chapter helps readers understand the research component methodology followed to obtain various conclusions as well as important qualitative and quantitative information about the protein A resin market.