Dermal Fillers Market Outlook from 2024 to 2034

The global sales of dermal fillers are estimated to be worth USD 6,411.8 million in 2024 and anticipated to reach a value of USD 8,819.6 million by 2034. Sales are projected to rise at a CAGR of 3.3% over the forecast period between 2024 and 2034. The revenue generated by dermal fillers in 2023 was USD 6,190.4 million.

Dermal fillers have evolved from being used as an anti-aging tool to currently proving to be versatile aspects that can be harnessed in most areas of dermatology and cosmetic procedures. The formulations may be applied in the induction of numerous benefits other than the reduction of wrinkles, in various forms, such as liquids, biological fragments, suspensions of microparticles, or microspheres.

Wide applications of these fillers are considered a wide application, thereby driving the dermal fillers market. Diverse use always increases applicability and importance in both aesthetic and therapeutic areas. Each dermal filler shows its technique of delivery with possible disadvantages.

For example, liquid fillers may have less trauma associated with them but may require more frequent touch-up parts compared to microspheres or particulate suspensions which are long-acting.

Global Dermal Fillers Industry Assessment

Attributes Key Insights
Historical Size, 2023 USD 6,190.4 million
Estimated Size, 2024 USD 6,411.8 million
Projected Size, 2034 USD 8,819.6 million
Value-based CAGR (2024 to 2034) 3.2%

Although anti-aging therapy continues to be one of the most publicized applications for dermal fillers, their roles go way beyond just eliminating wrinkles and fine lines. Rising versatility in its applications is a key driving force in the increased acceptance of dermal fillers, and this is a feature that allows for the treatment of a number of skin conditions and concerns.

One of the outstanding benefits of dermal fillers is that they can work together with other cosmetic treatments. An analogy for this is that Botox injections would typically work better when administered together with dermal fillers (or their derivatives, such as Xeomin). Botox precludes the deepening of wrinkles in such a manner that dermal fillers work in the smoothening of the wrinkles.

This sets a synergistic effect that is added to general aesthetical results, giving a more natural and prolonging effect. The dermal fillers are just coming up in the enhancing of the appearance of the scars. Hyaluronic acid, a common dermal filler component, facilitates the softening and easing of the scar tissue at the site of injection, thus smoothening of skin. This is widely in relation to acne scars or other types of post-traumatic scars.

With such diverse benefits, the market for dermal fillers is going up considerably, thereby leading to likely increased prominence within cosmetic as well as therapeutic dermatology.

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Semi Annual Market Update

The below table presents the expected CAGR for the global Dermal Fillers Market over several semi-annual periods spanning from 2024 to 2034. In the first half (H1) of the decade from 2023 to 2033, the business is predicted to surge at a CAGR of 4.0%, followed by a slightly higher growth rate of 3.7% in the second half (H2) of the same decade.

Particular Value CAGR
H1 3.9% (2023 to 2033)
H2 3.6% (2023 to 2033)
H1 3.2% (2024 to 2034)
H2 2.7% (2024 to 2034)

The above table presents the expected CAGR for the global dermal fillers market over several semi-annual periods spanning from 2024 to 2034. In the first half (H1) of the decade from 2023 to 2033, the business is predicted to surge at a CAGR of 3.9%, followed by a slightly decline in growth rate of 3.6% in the second half (H2) of the same decade.

Moving into the subsequent period, from H1 2024 to H2 2034, the CAGR is projected to decrease slightly to 3.3% in the first half and increase moderately at 2.7% in the second half. In the first half (H1) the market witnessed a decrease of -70.00 BPS while in the second half (H2), the market witnessed an increase of -90.00 BPS.

Key Industry Highlights

Multiple Applications of Dermal Fillers for Skin Benefits Is Driving the Overall Market Growth

The dermal fillers have grown into much larger applications in dermatology and aesthetic procedures. With products of liquid, biological fragment, suspension of particles, or microspheres forms of administration, these offer so much more than just wrinkle reduction.

This broad utility is, therefore, a high growth driver for the dermal fillers market, where their manifold uses continue to increase their scope in both aesthetic and therapeutic scenarios alike. Each of these types of dermal fillers has a delivery technique of its own and some associated drawbacks.

For example, while liquid fillers are relatively less invasive, they require frequent touching up compared to microspheres or particulate suspensions that produce more long-lasting effects.

Though anti-aging therapy stays one of the most recognized uses of dermal fillers, their uses go way beyond the smoothing of wrinkles and fine lines. One major growth driver in the dermal fillers market has been fast-growing versatility, with capabilities addressing a number of skin concerns and conditions. Some of the newer applications include.

An important advantage associated with dermal fillers is that they complement other beauty treatments. In most cases, results derived from dermal fillers come out better when complemented by Botox injections or its alternatives like Xeomin.

Such treatments as Botox, working by paralyzing facial muscles temporarily, avoid making wrinkles deeper, which are supposed to be smoothed out by the effect of dermal fillers. Consequently, such a combination will provide not only a better aesthetic effect but also a more natural and long-lasting one.

The role of these dermal fillers will become more prominent in cosmetic and therapeutic dermatology with these multiple benefits and a never-stopping market.

The Rising Demand for Minimally Invasive Surgical Procedures Significantly Contributes to The Growth of the Dermal Fillers Market.

Dermal fillers allow restorations of lost volumes and reductions of facial wrinkles, which are used to iron out contours very nicely into these inclinations. They produce immediate results with minimal discomfort, so they are very attractive in view of those looking to seek cosmetic improvements with no commitment or risks that come with surgery.

The International Society of Aesthetic Plastic Surgery has pointed out that in 2023, an estimated 34.9 million aesthetic procedures were performed worldwide by bringing together surgical and non-surgical treatments.

Moreover, further advances in injection methods and better imaging tools have developed new techniques and technologies that have also improved the accuracy and results in dermal filler cases. Such innovations increase growing interest in non-invasive procedures by promising more natural-looking outcomes and greater satisfaction of patients.

Most patients nowadays seek minimally invasive or non-invasive cosmetic procedures with very short recovery times. Essentially, people like a needle-based aesthetic procedure over a scalpel-based surgical procedure.

Other benefits that come with effective recovery with short treatment times usually measured in minutes or hours rather than days increase the demand towards such procedures. Besides, needle-based injections or other non-invasive procedures are relatively cheap and offer all-round better results hence in high demand.

Transition Toward Organic and Synthetic Dermal Fillers Represents Potential Opportunities in Dermal Fillers Market

With organic and synthetic fillers, dermal fillers market development becomes radically different. It is driven by changing consumer behavior, the quest for safe and effective cosmetics applications, and the advancement of materials science. Due to the maturity of these types of fillers, a multitude of innovation opportunities is opened for this market, which offers a wide variety of new benefits and satisfies diverse needs in the field of cosmetics.

Organic dermal fillers are naturally derived or contain biological material. Mostly, they are composed of materials that mock or contain the natural material found in the human body. An example includes: Naturally found in the human body, HA is widely applied to dermal fillers because of its biocompatibility and hydrating features. It also promotes skin moisture and volume, and it is used in this respect for facial volumization or wrinkle reduction.

Synthetic fillers are manufactured chemically to imitate or create an enhanced version of what happens in nature. They possess some advantages, which include controlled properties and results that can last a bit longer. The FDA-approved poly-l-lactic acid (PLLA) is a synthetic material that promotes the body's collagen production over some time.

Due to the reason that it induces collagen synthesis overtime, PLLA is utilized in fillers for replacing lost facial volume and creating long-lasting outcomes.

It would hence mean new opportunities for market growth and differentiation of products, catering to a wide array of consumer preferences, advancing safety and efficacy, and encouraging innovation.

High Cost of Physician Services for Procedures and Several Sessions for Desired Results is Challenging the Overall Market Growth

The cost of the procedure of dermal fillers and the number of sessions needed to achieve the desired result are acting as a restraint for the benefit of the dermal fillers market.

The physician or surgeon costs around 40 to 50% of the cost of the dermal filler. Fillers, such as Hyaluronic Acid, Poly-L-Lactic Acid, Calcium Hydroxylapatite, and collagen, are biodegradable, and their life varies from 3 to 24 months.

Many of them occur naturally in the body and as such, degrade very fast, so to attain the results desired, multiple sessions may be required, incurring an extra cost of the overall procedure. Also, it requires frequent visits to the physician or surgeon.

Furthermore, patients have been concerned about repeated sessions due to the resorbable nature of dermal fillers. It is the insistent control regarding the availability of permanent fillers that creates the opportunity.

Permanent fillers are deemed nonbiodegradable as well as irreversible and, hence, predictable, complications involved in the inflammatory reaction are likely predominantly to be associated with them. The HA's are distinguished from each other based on their cross-linking, gel particle size and concentration.

Bigger particle sizes give hydrophilic properties and higher concentrations give higher tissue swelling after the procedure. A product longevity increases with a larger concentration, large particle size lengthens the life of the product; strong cross-linking of the product might lead to more significant adverse reactions.

In brief, while dermal fillers are least invasive treatment options for the enhancement of cosmetic appearance, the high cost of consultation services by physicians and multiple sessions for their applications to achieve and maintain the results act as major restraints in its widespread acceptability.

Sabyasachi Ghosh
Sabyasachi Ghosh

Principal Consultant

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2019 to 2023 Global Dermal Fillers Sales Outlook Compared to Demand Forecast from 2024 to 2034

The global Dermal fillers industry recorded a CAGR of 6.6% during the historical period between 2019 and 2023. The growth of Dermal fillers industry was positive as it reached a value of USD 1,400.6 million in 2023 from USD 1,970.5 million in 2019.

It can be said that the market for dermal fillers will experience substantial growth, mainly due to a higher consumer interest in non-invasive aesthetic procedures. Increased social preference for minimally invasive treatment options propelled this trend as consumers sought cosmetic enhancements that provided immediate results with little chance of adverse reactions.

Among all types of dermal fillers, hyaluronic acid (HA) based products stand out as the most common because; they provide natural-looking results with great safety records.

Technological developments in the area of fillers are one of the major drivers of this market growth. Advanced injection techniques and new formulations in today's dermal fillers have created a more effective, long-lasting, and safe product.

Such innovations include fillers with more stable cross-linking and textures that can be modulated for better precision in applications to better personalize treatment for patients. Moreover, it has also increased the scope of fillers within aesthetic treatments from subtle lip enhancement to more extensive facial volumization.

Being naturally occurring in the skin, HA-based fillers are commonly thought about and most often accepted as being relatively safer and 'better' than most other products. The development of newer forms of HA has added a big boost to its use as these give much more extended outcomes.

Market Concentration

Tier 1 companies comprise market leaders with a market revenue of above USD 1000 million capturing significant market share of 63.2% in global market. These companies focus on developing a broadened range of fillers that would cater to different aesthetic needs and skin types.

Strategic partnerships or collaborations are formed by the companies with aesthetic professionals so as to improve the visibility and adoption of the products at hand. More so, such corporations have strong marketing campaigns on education aimed at improving awareness and building consumers' trust in products. Prominent companies in tier 1 include Allergan plc. (AbbVie), Galderma Pharma S.A and Mars Pharma GmbH & Co. KGaA.

Tier 2 companies include mid-size players with revenue of USD 500 to 1000 million having presence in specific regions and highly influencing the local market and holds around 24.1% market share. They frequently enter into strategic alliances with smaller clinics and aesthetic practitioners to increase their reach in the market, thereby increasing the adoption of products.

Prominent companies in tier 2 include Zimmer Aesthetics, Croman Pharma, Polonium Medical Technologies Inc. and others.

Finally, Tier 3 companies, such as Texan Laboratories Inc. Atoderm GmbH, Intracellular Medical UK Ltd, LKC Pharma and others. They specialize in specific products and cater to niche markets, adding diversity to the industry.

Overall, while Tier 1 companies are the primary drivers of the market, Tier 2 and 3 companies also make significant contributions, ensuring the dermal fillers sales remains dynamic and competitive.

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Country-wise Insights

The section below covers the industry analysis for the Dermal Fillers Market for different countries. Market demand analysis on key countries in several regions of the globe, including North America, Asia Pacific, Europe, and others, is provided. The United States is anticipated to remain at the forefront in North America, with higher market share through 2034. In Asia Pacific, India is projected to witness a CAGR of 7.6% by 2034.

Countries Value CAGR (2024 to 2034)
USA 1.6%
Germany 2.3%
China 7.1%
France 2.5%
India 7.6%
UK 6.1%
Japan 6.2%
South Korea 3.6%

China’s Dominance in the Dermal Fillers Market Driving Growth with lucrative CAGR

In the dermal fillers market, China has begun to turn out to be a prime influential force. The said region is likely to rise at a remarkable CAGR of 7.1%. A number of reasons may be attributed to this growth. First, the growing disposable income among the consumers in China is boosting demand for aesthetic procedures like dermal fillers.

While the middle class grows and consumer expenditure on beauty and wellness continues to rise, more people are turning towards non-surgical cosmetic enhancement procedures. Heavy investment in research and development by Chinese companies has led to new technologies in dermal fillers.

The quality of products, and more importantly, safety and efficacy have hugely improved by local manufacturers, thus helping them position at par with global competitors.

Also, growing acceptance of aesthetic procedures in China and innovations in the area of fillers will help the market grow.

The presence of prominent dermal fillers manufacturers and suppliers in United Kingdom

The UK has robust growth of 6.1% CAGR, which is helping it take a prime position in the global dermal fillers market.

Demand for dermal fillers is further fueled by growing awareness of non-surgical aesthetic treatment. Recently more and more people have started embracing non-invasive cosmetic procedures and dermal fillers being a popular choice among target population.

The UK is a country with an extremely well-established and organized healthcare system, accompanied by ultramodern medical infrastructure. All this, together with leading aesthetic clinics and top practitioners implementing the most modern techniques, attracts a large number of patients for the administration of dermal fillers.

The dermal filler brands and practitioners from the UK are very well-known across the world. In general, British products and services have the reputation of being of high quality and reliable, which does help UK companies do business overseas.

India’s Adoption of Advanced Technologies and Techniques in The Cosmetic Industry Is Propelling the Dermal Fillers Market Forward.

India has emerged as a vital market in the global dermal fillers market growing at an impressive CAGR of 7.6%. This captures manifold changes encompassing changing consumer preferences and expanding market dynamics. Currently, India holds the maximum share in the Asia Pacific region.

India has opened up the field to a greater number of international clientele who seek these cosmetic procedures at competitive prices, thus further fueling the demand for dermal fillers. Multi-specialty and advanced health facilities, coupled with trained professionals, are on the rise in India, thereby increasing access to and improving the quality of treatments regarding cosmetics.

With a large, youthful population getting interested in aesthetics and personal grooming, India exposes a burgeoning market for cosmetic enhancements.

Category-wise Insights

The section contains information about the leading segments in the industry. By ingredients, the hyaluronic acid segment holds the highest market share of 58.8% in 2024.

Hyaluronic Acid the Preferred Choice in The Dermal Fillers Market, Driving Its Widespread Use and Market Leadership.

By Ingredients Hyaluronic Acid
Value Share (2024) 58.8%

Hyaluronic acid is naturally available in the human body, particularly in the skin tissue, eyes, and other body connective tissues. It is a sponge that holds the moisture in the skin, providing hydration and volume.

Biocompatibility makes HA the ultimate ingredient in formulating dermal fillers since it would offer reduced chances of an adverse reaction or allergies compared to synthetic materials. This natural origin will, therefore, appeal to consumers who prefer treatments that work in harmony with the physiology of the body.

HA fillers can easily be dissolved in the presence of an enzyme called hyaluronidase if needed, providing both doctors and patients with peace of mind. It is the reversibility of this filler that enables confidence in choosing HA-based fillers; clients realize this is not permanent and can be adjusted.

The rapid growth of the dermal fillers market, as a result of rising demand from consumers for non-surgical, minimally invasive procedures, is also characterized by a corresponding innovation continuum in HA filler technology. In this scenario, hyaluronic acid-based fillers will retain their lead, driven by the growing demand from consumers for safety, efficacy, and natural looks-promising further innovation and expansion in the near future.

The strong market presence of wrinkle reduction is also reinforced by the growing number of aesthetic clinics and trained practitioners offering specialized treatments.

By Application Wrinkle Reduction
Value Share (2034) 23.2%

As individuals age, the degeneration of collagen and elastin takes place, leading to the formation of wrinkles and fine lines at the skin surface. Dermal fillers have become the most sought-after form of treatment in non-surgical means of addressing these signs of aging because it substantially restores the skin to a smooth texture, replenishes face volume, and improves skin quality.

This is complemented by the growing number of aesthetic clinics and trained aesthetic practitioners who are offering specialized treatments, which in turn strengthen the solid foothold wrinkle reduction has in the market. With wrinkle reduction fillers and a variety of other dermal fillers on the market, their leading edge is solidly affirmable even with the efficacy of the treatments.

Competitive Landscape

The market players are using strategies to stay competitive, such as product differentiation through innovative formulations, strategic partnerships with healthcare providers for distribution. Another key strategic focus of these companies is to actively look for strategic partners to bolster their product portfolios and expand their global market presence.

Recent Industry Developments in Dermal Fillers Market

  • In June 2023, Hugel Aesthetics Sponsorship with Pride 2023 Toronto promoted the Modern Aesthetics for A Modern World.
  • In April 2023, Croma launched PhilArt, a comprehensive line of injectable skin enhancers. PhilArt, a long-chain polynucleotide-based injectable gel, enhances radiance by rejuvenation, restores skin elasticity, promotes hydration and scavenges free radicals, creates the ideal environment for the growth of fibroblasts and fibers, and stimulates the body's cell regeneration.
  • Prollenium Medical Technologies, a manufacturer of cosmetics, introduced in January 2023 its customer-facing brand website. According to Prollenium, the portal is intended to provide the readers with all useful information concerning the safety profile and efficacy data of the products, as well as clinical claims data, and support realistic, achievable results.

Key Players of Dermal Fillers Market

  • Galderma Pharma S.A
  • Merz Pharma GmbH & Co. KGaA
  • Sinclair Pharma plc. (Huadong Medicine Co., Ltd)
  • Zimmer Aesthetics
  • Croma Pharma
  • Prollenium Medical Techhnologies Inc.
  • Suneva Medical, Inc
  • BioScience GmbH
  • Bioxis Pharmaceutical
  • Teoxane Laboratories Inc.
  • Adoderm GmbH
  • Intracell Medical UK Ltd
  • LKC Pharma
  • Shanghai Reyoungel Medical Technology Company Limited
  • Molderm Aesthetics AB.
  • Novepharma Inc. (HERMOSA)
  • Celiraz Europe S.L.
  • My Med Kft.
  • IBSA Farmaceutici Italia Srl
  • Laboratoires VIVACY
  • JETEMA, Co., Ltd. (E.P.T.Q)
  • Bioscience
  • Intraline
  • Professional Derma SA
  • Vida S.r.l.
  • Maxigen Biotech Inc.
  • Hangzhou Singclean Medical Products Co., Ltd
  • Oreon Life Science Co. Ltd.
  • CAREGEN LTD.
  • DongKook Pharmaceutical Co., Ltd.
  • EXCOBIO CO., LTD.
  • Across Co., LTD.
  • Regen Biotech, Inc.
  • LG Chem, Ltd.
  • Hugel Pharma
  • Medytox Inc.

Key Segments of Dermal Fillers Market

By Ingredient:

In terms of ingredients, the industry is divided into (hyaluronic acid, oly-L-lactic acid, calcium hydroxylapatite, polymethyl methacrylate, collagenm and polynucleotide (PN).

By Gender:

In terms of gender, the industry is segregated into (male, female & transgender).

By Application:

In terms of application, the industry is segregated into (wrinkle reduction, skin folds/ nasolabial folds, augmentation of lips, cheek &chin, scar treatment, hand rejuvenation, jawline and chin lines countering, eyebrows treatment, hollowness under eyes, nose jobs, volume restoration, restoring damaged tissues, restoration of facial fat loss and dentistry).

By Distribution Channel:

In terms of distribution channel, the industry is segregated into cosmetic and aesthetic clinics, hospitals, online sales, plastic surgery centers and medical spa.

By Region:

Key countries of North America, Latin America, Western Europe, Eastern, South Asia, East Asia and Middle East and Africa (MEA) have been covered in the report.

Frequently Asked Questions

What is the future of global dermal fillers market?

The global dermal fillers market is projected to witness CAGR of 3.3% between 2024 and 2034.

What was the worth of the global dermal fillers market in 2023?

The global Dermal fillers industry stood at USD 6,190.4 million in 2023.

What will the worth of global dermal fillers market by 2034 end?

The global Dermal Fillers Market is anticipated to reach USD 8,819.6 million by 2034 end.

Which country to showcase the highest CAGR during forecast period?

India is set to record the highest CAGR of 7.6% in the assessment period.

Who are the key manufacturer of dermal fillers?

The key players operating in the global dermal fillers market include Galderma Pharma S.A, Merz Pharma GmbH & Co. KGaA, Sinclair Pharma plc. (Huadong Medicine Co., Ltd), Zimmer Aesthetics, Croma Pharma, Prollenium Medical Techhnologies Inc., Suneva Medical, Inc, BioScience GmbH, Bioxis Pharmaceutical, Teoxane Laboratories Inc., Adoderm GmbH, Intracell Medical UK Ltd, LKC Pharma

Table of Content
1. Executive Summary
2. Industry Introduction, including Taxonomy and Market Definition
3. Market Trends and Success Factors, including Macro-Economic Factors, Market Dynamics, and Recent Industry Developments
4. Global Market Demand (Value in USD) and Volume (Units) Analysis 2019 to 2023 and Forecast 2024 to 2034, including Historical Analysis and Future Projections
5. Global Market - Pricing Analysis
6. Global Market Analysis 2019 to 2023 and Forecast 2024 to 2034
    6.1. By Ingredients
    6.2. By Gender
    6.3. By Application
    6.4. By Distribution Channel
    6.5. By Region
7. Global Market Analysis 2019 to 2023 and Forecast 2024 to 2034, By Ingredients
    7.1. Hyaluronic Acid
    7.2. Poly-L-Lactic Acid
    7.3. Calcium Hydroxylapatite
    7.4. Polymethyl methacrylate
    7.5. Collagen
    7.6. Polynucleotide (PN)
8. Global Market Analysis 2019 to 2023 and Forecast 2024 to 2034, By Gender
    8.1. Male
    8.2. Female
    8.3. Transgender
9. Global Market Analysis 2019 to 2023 and Forecast 2024 to 2034, By Application
    9.1. Wrinkle Reduction
    9.2. Skin Folds/ Nasolabial Folds
    9.3. Augmentation of Lips, Cheek & Chin
    9.4. Scar Treatment
    9.5. Hand Rejuvenation
    9.6. Jawline and Chin Lines Countering
    9.7. Eyebrows Treatment
    9.8. Hollowness Under Eyes
    9.9. Nose Jobs
    9.10. Volume Restoration
    9.11. Restoring Damaged Tissues
    9.12. Restoration of Facial Fat Loss
    9.13. Dentistry
10. Global Market Analysis 2019 to 2023 and Forecast 2024 to 2034, By Distribution Channel
    10.1. Cosmetic and Aesthetic Clinics
    10.2. Hospitals
    10.3. Online Sales
    10.4. Plastic Surgery Centers
    10.5. Medical Spa
11. Global Market Analysis 2019 to 2023 and Forecast 2024 to 2034, By Region
    11.1. North America
    11.2. Latin America
    11.3. Western Europe
    11.4. Eastern Europe
    11.5. South Asia & Pacific
    11.6. East Asia
    11.7. Middle East & Africa
12. North America Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
13. Latin America Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
14. Western Europe Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
15. Eastern Europe Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
16. South Asia & Pacific Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
17. East Asia Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
18. Middle East and Africa Sales Analysis 2019 to 2023 and Forecast 2024 to 2034, by Key Segments and Countries
19. Sales Forecast 2024 to 2034 by ingredients, by application by gender, by application and by distribution channel Form for 30 Countries
20. Competition Outlook, including Market Structure Analysis, Company Share Analysis by Key Players, and Competition Dashboard
21. Company Profile
    21.1. Galderma Pharma S.A
    21.2. Merz Pharma GmbH & Co. KGaA
    21.3. Sinclair Pharma plc. (Huadong Medicine Co., Ltd)
    21.4. Zimmer Aesthetics
    21.5. Croma Pharma
    21.6. Prollenium Medical Techhnologies Inc.
    21.7. Suneva Medical, Inc
    21.8. BioScience GmbH
    21.9. Bioxis Pharmaceutical
    21.10. Teoxane Laboratories Inc.
    21.11. Adoderm GmbH
    21.12. Intracell Medical UK Ltd
    21.13. LKC Pharma
    21.14. Shanghai Reyoungel Medical Technology Company Limited
    21.15. Molderm Aesthetics AB.
    21.16. Novepharma Inc. (HERMOSA)
    21.17. Celiraz Europe S.L.
    21.18. My Med Kft.
    21.19. IBSA Farmaceutici Italia Srl
    21.20. Laboratoires VIVACY
    21.21. JETEMA, Co., Ltd. (E.P.T.Q)
    21.22. Bioscience
    21.23. Intraline
    21.24. Professional Derma SA
    21.25. Vida S.r.l.
    21.26. Maxigen Biotech Inc.
    21.27. Hangzhou Singclean Medical Products Co., Ltd
    21.28. Oreon Life Science Co. Ltd.
    21.29. CAREGEN LTD.
    21.30. DongKook Pharmaceutical Co., Ltd.
    21.31. EXCOBIO CO., LTD.
    21.32. Across Co., LTD.
    21.33. Regen Biotech, Inc.
    21.34. LG Chem, Ltd.
    21.35. Hugel Pharma
    21.36. Medytox Inc.
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