Cell Dissociation Market Outlook 2023 to 2033

The cell dissociation market is projected to achieve a valuation of USD 352.91 million by 2023, with a CAGR of 13.55% from 2023 to 2033. The cell dissociation business is projected to have a turnover of USD 1,257.59 million by 2033.

Cell dissociation is an essential activity in biopharmaceutical research since it’s involved in medication development and disease explanation. As a result, higher research and development spending by biopharmaceutical companies is spearheading cell dissociation market expansion.

The sector is expanding to assist researchers and pharmaceutical companies in their efforts to study, and use cells. Since cell culture technology played a significant role in identifying therapeutic and innovative diagnostic alternatives, the pandemic increased demand.

The cell dissociation market is expanding due to the crucial tools that culturing techniques for vaccine development. The primary factor fueling the cell dissociation industry expansion is the increased emphasis on creating cell-based therapies. Market expansion is being fueled by an increase in clinical trials, FDA approvals, and strategic moves by leading companies.

  • Sanofi and Innate Pharma SA increased their cooperation with Sanofi for natural killer cell therapies in oncology in 2022.
  • Collaboration and license agreement to develop four iPSC-derived initiatives was announced by Century Therapeutics and Bristol Myers Squibb in September 2022.

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Key Influential Parameters

  • The predominance of cell-based research launched by pharmaceutical and biotechnology businesses fuels the cell dissociation industry expansion.
  • Numerous pharmaceutical and biotech companies are growing globally. This is another aspect pushing the cell dissociation market forward.
  • The biotechnology industry requires improved enzymes that aid in tissue dissociation. This cell dissociation demand propels the market forward.

Although, in several areas, ethical constraints and concerns about the use of cell-based research limit the progress of cell biology.

Market Outlook: 2018 to 2022 versus the Future 2023 to 2033

The cell dissociation market was worth USD 200.25 million in 2018, with a CAGR of 12% from 2018 to 2022. By 2022, the cell dissociation business reached a revenue of USD 315.10 million.

The market, on the other hand, is estimated to be worth USD 352.91 million by 2023, with a CAGR of 13.55% through 2033. By 2033, the cell dissociation business is expected to have a revenue of USD 1,257.59 million.

Shift Toward Enzymatic Dissociation: Conventionally, mechanical methods were commonly used to break down tissue and cells. In recent years, there has been a significant shift toward enzymatic methods, which are efficient and gentler on cells.

Development of New Dissociation Reagents: Over the years, researchers have developed new and improved dissociation reagents, including proteolytic enzymes and chelating agents. This has enabled the dissociation of a wider range of cell types and tissues with greater accuracy and efficiency.

Increased Demand for Animal-free and Xeno-free Dissociation Reagents: With the rise of regenerative medicine and cell-based therapies, there has been a growing demand for animal-free and xeno-free dissociation reagents. It helps to reduce the risk of contamination and improves cell viability.

Growth in Stem Cell Research: The use of cell dissociation methods has become increasingly important in the field of stem cell research. As dissociated cells are often used to generate induced pluripotent stem cells (iPSCs) and other cell types for research and therapeutic applications.

Advancements in Cell-based Therapies: The development of cell-based therapies, such as CAR-T cell therapy and stem cell transplantation, has driven dissociation reagents demand and enzymes for the isolation and therapeutic cell expansion.

Growing Research in Drug Discovery: The use of cell-based assays in drug discovery has led to increased demand for dissociation reagents and enzymes to isolate and culture cells for high-throughput screening.

Attributes Details
Cell Dissociation Market HCAGR (2018 to 2022) 12%
Cell Dissociation Market CAGR (2023 to 2033) 13.55%
Cell Dissociation Market Size (2022) USD 315.10 million
Cell Dissociation Market Size (2023) USD 352.91 million
Cell Dissociation Market Size (2033) USD 1,257.59 million
Sabyasachi Ghosh
Sabyasachi Ghosh

Principal Consultant

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Technological Breakthroughs in Cell Dissociation Products Foster Market Growth

The rising interest in personalized medicine and regenerative medicine is set to propel the demand for cell dissociation solutions. Cell dissociation is a critical stage that involves evaluating a patient's genetic profile to determine specific treatment options.

Cell dissociation materials are used to develop cell-based therapies and regenerative medicine solutions. As chronic and infectious diseases grow increasingly widespread, demand for cell dissociation products is likely to rise. Cell-based assays are used to diagnose and treat diseases such as cancer, Alzheimer's disease, and diabetes.

The technological advancements in cell dissociation products are propelling the market's revenue. With the development of reagents and kits that provide efficient cell dissociation, the usage in research and development applications may increase.

Efficient Usage of Automation in Cell Dissociation Pushes Market Forward

The increased application of automation in cell dissociation is positively influencing market revenue growth. By reducing human error, automating the cell dissociation processes boosts productivity.

Another element promoting the uptake of automated cell dissociation systems is the growing need for high-throughput screening in drug discovery and development. The utilization of products to rise as integrated systems that combine cell dissociation with subsequent processing procedures is evolved.

The increased requirement for research and development in biopharmaceutical firms is a key reason driving cell dissociation market expansion. The favorable financing landscape for cancer research and the rising incidence and prevalence of diseases stimulate market growth.

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Roadblocks of the Market

The rising expense of cell-based research and the lack of infrastructure for cell-based research in developing nations may stymie market expansion. The intricacies of cell dissociation operations, as well as a scarcity of qualified personnel limit cell dissociation market revenue growth.

The growing emphasis on customized medicine and increased government support for cell-based research is expected to deflate market growth. Alternative cell dissociation procedures, such as sonication and freeze-thaw cycles, are expected to limit market revenue growth. Although, Small firms and new entrants may pose a threat to the growth of the cell dissociation industry.

Segmentation Outlook

Which Products Have a Substantial Market Share?

Attribute Details
Enzymatic dissociation Segment Share 47.9%
Leading CAGR Segment Non-enzymatic Segment

In 2023, the enzymatic dissociation segment dominated the global industry and held a significant share. Enzymatic dissociation is a technique that uses enzymes to break down the cut-up tissue fragments, freeing the cells from the tissue. Many types of enzymes are utilized in the dissociation process, and they can also be used in tandem.

All enzymatic dissociations are more successful and efficient in separating mononuclear cells from the spinal cord and brain. From 2023 to 2033, the non-enzymatic segment is expected to rise at a significant CAGR.

The enzyme-free formulation aids in the preservation of the functional and structural integrity of cell surface proteins. It also has the advantage of avoiding the cytotoxic effects of chelating drugs. The usage of animal-derived components is subjecting biopharmaceutical manufacturers to increased regulatory scrutiny.

Non-enzymatic products for cell culture are needed, which might accelerate category expansion. The solution is not recommended for cells with unique sticky qualities. The biopharmaceutical sector has created a Papain Dissociation Solution for difficult-to-remove cell lines.

Which Cell Dissociation Type is Going to Gain a Significant Market Revenue Share?

Attribute Details
Tissue Dissociation Type Segment Share 56.55%
Leading CAGR Segment Cell Detachment Type Segment

The industry has been divided into two types: tissue dissociation and cell detachment. The tissue dissociation type segment led the global industry in 2022, accounting for a huge proportion.

The segment may continue to increase at a steady rate, retaining its dominant position in the global market. Factors such as the increased focus of biopharmaceutical and pharmaceutical firms on the development of monoclonal antibodies and therapy customization may drive the expansion of this segment.

Cell detachment type segment, on the other hand, is expected to develop at a significant rate during the projection period. Cell detachment is essential in the culture of adherent cells. The most prevalent method of separation is trypsinization.

Increasing investment in cell culture product launches and strategic initiatives by leading industry players are among the fundamental factors driving this segment's growth.

Which End User Segment is Highly Prolific Globally?

Attribute Details
Pharmaceutical and Biotechnology Companies Segment Share 71.60%
Leading CAGR Segment Pharmaceutical and Biotechnology Companies Segment

The industry has been subdivided into pharmaceutical and biotechnology enterprises, as well as research and academic institutes, based on end-users. During the projection period, the category is projected to develop at a considerable CAGR while maintaining its prominent position in the global market.

This segment's significant portion and rapid growth can be due to the extensive usage of cell dissociation enzymes in pharmaceuticals. Collagenase and trypsin are key enzymes for preserving solid tissues and adherent cells for culturing and research.

Cell tissue disaggregation and dissociation represent the beginning of a wide range of research applications, including cancer treatments, cell multiplication, and vaccine manufacture.

Regional Outlook

Why is North America Exhibiting High Cell Dissociation Demand?

Attribute Details
North America Market Share 37.20%

North America dominated the global industry in 2023, accounting for around 37.20% of total revenue. The region's huge proportion can be linked to the government's increased investment initiatives, the increasing frequency of chronic diseases such as cancer, and the presence of high-quality infrastructure for clinical and laboratory research in the region.

  • According to the Globocan study, about 2,281,658 new cancer cases were documented in the United States in 2020, with nearly 612,390 deaths.

The rising frequency of chronic and infectious diseases, combined with a greater emphasis on cell-based treatments, is broadening the market's potential prospects.

What is the Reason behind Asia Pacific's Rising Cell Dissociation Demand?

Due to increased demand for innovative treatments, the Asia Pacific region to develop at a swift rate throughout the forecast period. Rising government investments and rapid infrastructure development are significant drivers of booming market expansion. Some regional businesses are receiving financing to investigate treatments for chronic diseases such as cancer.

  • Immuneel Therapeutics, for example, won a USD 15 million budget in June 2022 to develop cheap cell and gene therapy for cancer patients in India.

How Can Competitive Pressure Shape the Cell Dissociation Market?

To increase their market position, leading firms are using a variety of techniques, such as the introduction of novel products, partnerships, collaborations, mergers & acquisitions, and geographic growth.

  • S2 Genomics introduced the Singulator 100 System in February 2020. For a wide range of genomic analyses and single-cell biology, the system automates the processing of solid tissue samples into suspensions of nuclei or single cells with high yields and from tiny samples. The device standardizes the process for separating solid tissues, making it easy for researchers to consistently create suspensions of excellent, highly viable nuclei or cells with little variation.

Developments in the Cell Dissociation Approach

  • Acquisitions
Date December 8, 2021
Company Thermo Fisher Scientific Inc.
Details Thermo Fisher Scientific Inc. purchased PPD, Inc., a well-known supplier of clinical research services. The deal, which was estimated to be worth USD 17.4 billion, was made to strengthen Thermo Fisher Scientific's position in the life sciences industry.
Date April 9, 2020
Company Bio-Rad Laboratories, Inc.
Details Bio-Rad Laboratories, Inc. purchased Celsee, Inc., a top producer of single-cell analysis tools. The goal of the acquisition was to increase the range of single-cell analytic products offered by Bio-Rad Laboratories.
Date June 1, 2020
Company Straub Medical AG
Details Straub Medical AG, a significant supplier of medical tools for the detection and treatment of venous diseases, was acquired by Becton, Dickinson and Company. The acquisition aimed to increase the range of products offered by the Company in the vascular access sector.

Key Players

  • HiMedia Laboratories
  • F. Hoffmann-La Roche Ltd.
  • Merck KGaA
  • Thermo Fisher Scientific
  • Sartorius AG
  • S2 Genomics, Inc.
  • Danaher Corp.
  • STEMCELL Technologies
  • BD
  • Miltenyi Biotec
  • PAN-Biotech

Key Segments

Cell Dissociation Industry by Product:

  • Enzymatic dissociation
  • Non-enzymatic dissociation
  • Instruments & Accessories

Cell Dissociation Industry by Type:

  • Cell dissociation for Tissue Dissociation
  • Cell dissociation for Cell Detachment

Cell Dissociation Industry by End User:

  • Cell dissociation for Pharmaceutical and Biotechnology Companies
  • Cell dissociation for Research and Academic Institutes

Cell Dissociation Industry by Region:

  • Cell dissociation in North America Market
  • Cell dissociation in Latin America Market
  • Cell dissociation in Europe Market
  • Cell dissociation in East Asia Market
  • Cell dissociation in South Asia and Pacific Market
  • Cell dissociation in The Middle East and Africa (MEA) Market

Frequently Asked Questions

How Big is the Cell Dissociation Market?

The market is valued at USD 352.91 million in 2023.

What is the Growth Potential of the Cell Dissociation Market?

The overall market is projected to surge at a 13.55% annual growth rate through 2033.

What is the Predicted Size of the Cell Dissociation Market in Ten Years?

The market is estimated to be worth USD 1,257.59 million by 2033.

How Big is the Enzymatic Dissociation Market Segment?

This segment held 47.9% of the global market share in 2022.

Which is the Prominent Cell Dissociation Type Market Segment?

The tissue dissociation segment accounted for 56.55% of the total market share in 2022.

Table of Content
  • 1. Executive Summary 
  • 2. Market Overview
  • 3. Market Background
  • 4. Global Market Analysis 2018 to 2022 and Forecast, 2023 to 2033
  • 5. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Product
    • 5.1. Enzymatic Dissociation
    • 5.2. Non-enzymatic Dissociation
  • 6. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Type
    • 6.1. Tissue Dissociation
    • 6.2. Cell Detachment
  • 7. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By End-use
    • 7.1. Pharmaceutical and Biotechnology Companies
    • 7.2. Research & Academic Institutes
  • 8. Global Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Region
    • 8.1. North America
    • 8.2. Latin America
    • 8.3. Europe
    • 8.4. South Asia
    • 8.5. East Asia
    • 8.6. Oceania
    • 8.7. MEA
  • 9. North America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 10. Latin America Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 11. Europe Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 12. South Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 13. East Asia Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 14. Oceania Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 15. MEA Market Analysis 2018 to 2022 and Forecast 2023 to 2033, By Country
  • 16. Key Countries Market Analysis
  • 17. Market Structure Analysis
  • 18. Competition Analysis
    • 18.1. Merck KGaA
    • 18.2. Thermo Fisher Scientific
    • 18.3. Danaher Corp.
    • 18.4. STEMCELL Technologies
    • 18.5. Sartorius AG
    • 18.6. Miltenyi Biotech
    • 18.7. PAN-Biotech
    • 18.8. HiMedia Laboratories
    • 18.9. F. Hoffmann-La Roche Ltd.
    • 18.10. S2 Genomics, Inc.
  • 19. Assumptions & Acronyms Used
  • 20. Research Methodology
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