The closed system bioprocessing market was valued at USD 10.9 billion in 2025. The market is projected to reach USD 11.8 billion in 2026 and USD 27.4 billion by 2036, expanding at a CAGR of 8.8% during the forecast period. Single-use bags and assemblies are expected to lead product type with a 31.4% share in 2026. Upstream processing is projected to remain the leading workflow with a 46.7% share in 2026. Biopharmaceutical manufacturers are expected to lead end-user demand with a 57.9% share in 2026.