Tissue Engineered Skin Substitute Market

2019 Analysis and Review of Tissue Engineered Skin Substitute Market by Product - Acellular Skin Substitute, Cellular Skin Substitute, Biologic Skin Substitute, and Synthetic Skin Substitute for 2019 - 2029


Increasing Prevalence of Chronic Wounds Boosting Demand for Skin Substitutes

Increasing prevalence of chronic wounds is one of the leading factors driving the growth of the tissue engineered skin substitute market. With the increasing prevalence of type I and maturity-onset diabetes in developed economies, the incidence of diabetic ulcers is growing rapidly. According to the Journal of Diabetic Research, the prevalence of diabetic ulcers is rising by 9% annually. Currently, there are more than 4.5 million pressure ulcer patients in the world that require treatment.

There are more than 9.7 million venous ulcers and approximately 10 million diabetic ulcer patients in the world requiring treatment. The number of pressure and venous ulcer patients has grown from 6% to 7% in developed countries, which is expected to increase the demand for tissue engineered skin substitutes.

Increasing Burn & Trauma Cases Driving Market Growth

Burns are a growing global concern. According to WHO, in 2004, nearly 11 million people worldwide were burned severely enough to require medical attention. Increasing number of burn and trauma cases are expected to accelerate the demand for tissue engineered skin substitutes. Road accidents and violence leading to traumatic injuries are also favoring the increased demand for tissue engineered skin substitutes.

According to the National Burn Repository (NBR) of the American Burn Association (ABA), annually around 486,000 burn injuries receive medical treatment in the U.S. The number of cases of burns is growing 1% to 2% annually, which is expected to surge the growth of the tissue engineered skin substitute market.

Increasing Focus on Technological Advancements in Tissue Engineering

Researchers are focusing on the emergence of new fabrication technologies in the field of skin tissue engineering, which is expected to provide an opportunity for the significant growth of the tissue engineered skin substitute market. Three-dimensional (3D) bioprinting and biotextile have emerged as powerful tools in the tissue engineered skin substitute market.

The fabrication of 3D structures with complex geometries by 3D printing has been recently used in tissue engineering of the skin. For instance, researchers from Universidad Carlos III de Madrid and Hospital General Universitario in Valencia, Spain, have created a 3D bioprinter that creates totally functional human skin in its natural layered structure.


  • The worldwide tissue engineered skin substitute market is a fairly competitive. Allergan Plc., MiMedx Group Inc., Integra LifeSciences Corp. and Smith & Nephew Plc. are the key players contributing to the maximum market share in terms of revenue.
  • New product launches are the main policy pursued by key participants in the tissue engineered skin substitute market.
  • The key players in the tissue engineered skin substitute are focusing on the development of new and technologically advanced designs of skin substitutes.

Tissue Engineered Skin Substitutes Gathering Traction on the Back of Chronic Wound Care Management

Deepening penetration of tissue engineered skin substitutes in advanced wound management and treatment of pressure ulcers, and diabetic foot ulcers reflects high market share of chronic wounds. Moreover, increasing demand for breast reconstruction surgery will further heighten growth prospects of market. Despite a marginal decline estimated over the next few years, use of tissue engineered skin substitute in chronic wounds will continue to witness an upshift in investments. Proliferation of redesigning trends is gradually shape-shifting this application category.

North America Leading, High Applicability in Diabetic Foot Ulcers

Market in North America would continue to lead, representing an absolute opportunity worth of over a billion-dollar during 2019 – 2029. Accounting for nearly half the global market revenues, demand in North America will be concentrated at biologic tissue engineered skin substitutes. Diabetic foot ulcers are identified as the top application area in this regional market. Europe, the second leading market for wound care, followed by Asia Pacific, will also be the significant investment pockets for stakeholders in tissue engineered skin substitute market.

Sharp Profit Margins for Leading Players, as New Product Variants Abound

Market leaders in tissue engineered skin substitute landscape such as Allergen Plc and MiMedx Group Inc collectively account for over 50% of market value. While these companies maintain focus on redesign innovations through R&D, the latter has launched over 45 patented varieties of placental tissues. The former also recently announced introduction of a new product, Strattice, a biological mesh used to repair torn hernias. The company is also strategizing on strengthening its market presence beyond developed regions.

How Growth will Unfold

Tissue contrived skin is one such noteworthy improvement in the area of wound healing and these substitutes provide a painless healing process, further encouraging the formation of vascular, neural and lymphatic networks. Biomaterial constructs or matrix to create functional skin has been introduced.

Biomaterial matrix are playing a significant role in the regeneration of functional tissue and this will continue to be a prolific trend throughout the forecast period. Besides this, tissue engineered products for wound care management which are biological in nature such as allografts and xenografts are gathering significant momentum. The market is all set to reap rich benefits with the advent of biologic tissue engineered skin substitutes, projected for more than twofold growth through 2029.


The global tissue engineered skin substitute market is segmented in detail to cover every aspect of the market and present a complete market intelligence approach to the reader.


  • Acellular Skin Substitute
  • Acellular skin substitute based on amniotic membrane
  • Other Acellular Skin Substiute
  • Biologic Skin Substitute
  • Allograft
  • Xenograft
  • Cellular Skin Substitute
  • Cellular skin substitute based on amniotic membrane
  • Other cellular skin substitute
  • Synthetic Skin Substitute


  • Synthetic
  • Natural


  • Chronic Wounds
  • Venous leg ulcers
  • Diabetic foot ulcer
  • Pressure Ulcers
  • Acute Wounds
  • Traumatic Wounds
  • Burn Cases
  • Other Applications

End User

  • Hospital
  • Specialty Clinics
  • Ambulatory Surgical Centers
  • Research Laboratory


  • North America
  • Latin America
  • Europe
  • South Asia
  • East Asia
  • Oceania
  • MEA 

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Tissue Engineered Skin Substitute Market