Amniotic membrane is the innermost layer of the placenta. Amniotic membrane transplantation (AMT) long being practiced in the ophthalmic surgery is emerging as a popular technique, due to recent developments in tissue preservation methods. Amniotic membrane has anti-inflammatory and anti-scarring effects. The growth factors present in the amniotic membrane promotes the epithelial wound healing of the surface of the eye. Amniotic membrane transplant is a better alternative for corneal and conjunctival reconstruction. The different ophthalmic disorders, such as persistent epithelial defects of cornea, mucous membrane disorders, and chemical burns, among others, are poised to be significant clinical challenges. Amniotic fluid transplantation technique, however, has brought revolutionary changes in reconstructive surgery of the eyes.
Market Value and Forecast
FMI estimates that the global market for amniotic membrane is expected to be valued at US$ 2,322.6 Mn by 2028 end, expanding at an impressive CAGR of 9.3% over 2018–2028. The cryopreserved amniotic membrane segment is expected to dominate the global market with above 70% revenue share in 2017. North America is expected to expand at higher single digit CAGR over the forecast period.
The global amniotic membrane market is expected to be driven by rise in the number of geriatric population, expansion of indications of amniotic membrane transplant, increased R&D investment in AMT by the key players, increasing focus on tissue – cell & stem cell research, unmet clinical needs, regulatory harmonization, etc. Besides, the increase in number of amniotic membrane transplants is likely influenced by introduction of distinctive surgical placenta-derived amniotic membrane transplant techniques, growing awareness regarding presence of growth factors and cytokines in amniotic membrane, and the demographic change constituting aging of the population. Moreover, the process of product approvals has been accelerating in the developed markets. Fast FDA approvals for amniotic membrane-based products such as suspensions and allografts to treat surgical wounds is contributing to the growth of the amniotic membrane market. However, the lack of skilled/experienced professionals to perform AMT and lack of standardized guidelines on tissue and bio-medical engineering are factors hampering the growth of the market.
Market Segmentation by Application
Based on treatment, the global amniotic membrane market has been segmented into,
Surgical wound application segment in amniotic membrane market dominated the global market in 2018 and is expected to follow the same trend during forecast period. Over 6.5 million patients in U.S. suffer with chronic wounds annually, out of which around 200,000 patients are treated using skin or dermal substitutes. Also, chronic wound market in U.S. alone offers a revenue opportunity of around US$ 3.0 Billion. Whereas, ophthalmology segment accounts for the second largest revenue share in global amniotic membrane market on the account of increased capability of amniotic membrane to enhance epithelial wound healing of the surface of the eye.
The global market for amniotic membrane is segmented in to eight key regions viz. North America, Latin America, Western Europe, Eastern Europe, Asia Pacific excluding Japan & China (APECJ), Japan, the Middle East and Africa (MEA) and China. North America accounted a high share of over 40% in 2017. APEJ is expected to witness double digit growth due to rising number of AMT procedures in India and China.
The global market for amniotic membrane is highly consolidated with top 5 players contributing over 65% revenue share in the global market. Examples of the key players identified in the global amniotic membrane market are Integra LifeSciences Inc., MiMedx Group, Inc., Alliqua BioMedical, Inc., Skye Biologics Inc., Katena Products, Inc., Tissue-Tech Inc., Amnio Technology, LLC, Applied Biologics LLC, Human Regenerative Technologies, LLC, etc.
This Future Market Insights (FMI) report examines the global amniotic membrane market for the period 2013–2028. The primary objective of the report is to offer insights into market opportunity for amniotic membrane and provide assessment of pipeline developments in amniotic membrane market.
The global amniotic membrane market has seen changes in landscape in the last decade. The key accomplishment in unlocking the potential for amniotic membrane to be used for the treatment of defects of the corneal epithelia has been attained by initiating mass extraction and storage of amniotic membrane for medical applications.
The market for amniotic membrane is primarily driven by increased adoption of amniotic membrane for various applications, financial investments for development of innovative amniotic membrane, increasing focus on tissue-cell and stem cell research, unmet clinical needs fuelling demand for regenerative therapies, increase in regulatory harmonization to accelerate pace of product approvals, rise in number of amniotic membrane transplants, etc. However, lack of skilled/experienced professionals, high gestation period and time-to-market due to lengthy clinical trials, lack of standardized guidelines on tissue and bio-medical engineering are the factors deterring the growth of the global market.
The Global Amniotic Membrane Market has been Segmented Based on:
The report analyses the global amniotic membrane market in terms of value (US$ Mn). The report begins with the market definition and explaining different types of amniotic membrane types available in the market. This section also provides an overview on dermal substitute market, to which amniotic membrane is a sub-part. The market view point section includes FMI’s analysis on key trends, drivers, opportunities and macro factors influencing the global market. Opportunity analysis provided in the section allows to better equip with crystal clear decision-making insights. Pipeline analysis provided in the subsequent section helps to identify future rivals in the global market.
The report analyses the market based on regions and presents the forecast in terms of value (US$ Mn) for the next 10 years. The regions covered in the report include:
Asia Pacific Excluding Japan & China (APEJC)
The Middle East and Africa (MEA)
Each of these sections analyse the regional market by product type, application, end users and country. The regional introductory section provides key insights on market dynamics for each region. The section is mainly designed to provide current scenario of the amniotic membrane market in the region and forecast for 2018–2028. The representative market participants section gives the list of companies operating in each region, competitive landscape and intensity map of their presence in each region.
To arrive at the market size, we have used our in-house epidemiology data-based model to estimate the amniotic membrane market size. We have adopted bottom-up approach to forecast the amniotic membrane market. The weighted average selling price is considered to estimate the market size of various product type mentioned in the scope of the study. The country price is captured with the local currency. The local currency figures are then converted to USD to offer forecasts in a consistent currency standard. Furthermore, FMI has also considered the latest annual exchange rate to reflect the impact of the most recent economic conditions of the countries. Prices considered in the models are standardized based on the type of amniotic membrane allografts used to treat patients.
The forecast presented in the report provides total revenue of currently approved amniotic membrane products over 2018–2028. In addition, we have taken into consideration the year-on-year growth to understand the predictability of the market and to identify the right growth opportunities in the global market.
In the next section of the report, the ‘Competitive Landscape’ is included to provide report audiences with a dashboard view and to access the key differentiators among the competitor firms. The market structure analysis provides tier-wise breakdown of total market revenue. The section also provides company share analysis and brand share analysis for the key market players. This section is primarily designed to provide clients with an objective and detailed comparative assessment of product offerings and strategies of key providers specific to the market segments. Detailed profiles of players operating in the global amniotic membrane market are also provided in the report, which highlight company description, overview, product/segment overview, SWOT analysis, financial information, key developments related to market and strategic overview. The key players covered in the report include Integra LifeSciences Inc., MiMedx Group, Inc., Alliqua BioMedical, Inc., Skye Biologics Inc., Katena Products, Inc., Tissue-Tech Inc., Amnio Technology, LLC, Applied Biologics LLC, and Human Regenerative Technologies, LLC, among others.
The next section of report analyses the market based on product types and forecast is provided in terms of value for the next 10 years. The product types covered in the report include:
Cryopreserved Amniotic Membrane
Lyophilized Amniotic Membrane
The next section of the report provides analysis based on application and the forecast is provided in terms of value for the next 10 years. The applications covered in the report include:
The next section of report analyses the market based on the end users of amniotic membrane products and provides the forecast in terms of value for the next 10 years. End users covered in the report include:
Ambulatory Surgical Centres
Academic Research Centres
Another key feature of this report is the analysis of the key segments in terms of absolute dollar opportunity. This is traditionally overlooked while forecasting the market. However, absolute dollar opportunity is critical for assessing the level of opportunity that a provider can look to achieve, as well as to identify potential resources from a sales and delivery perspective of the products. To understand the key growth segments, Future Market Insights provides the ‘Attractiveness Index’ analysis, which helps to identify real market opportunities.