The global autonomous ultrasound guidance market is projected to grow from USD 730.2 million in 2025 to USD 3,927.2 million by 2035, advancing at a CAGR of 18.3%. AI-enabled handheld autonomous ultrasound devices segment is expected to lead the market with a 43.4% share in 2025, while diagnostic imaging applications are anticipated to account for the majority of market demand across healthcare and medical sectors.