The global NSAID-acetaminophen combination analgesic market is projected to grow from USD 3,200.0 million in 2025 to USD 4,217.8 million by 2035, at a CAGR of 2.8%. By product type, OTC combination analgesics will dominate with 55% share, while by application, acute pain and headache indications will lead with 48% share in 2025.