Nasal Spray Market

What is the Future Demand Scenario for Nasal Sprays in Comparison to Historic Sales?

Nasal sprays are often used to treat symptoms of allergies and colds such as congestion, sneezing and runny nose. But they can be used for other purposes as well such as migraines. The demand for nasal spray has been rising since the past few years, in response to the increasing cases if allergic reactions. Rising awareness for palliative care and favorable reimbursement policies, along with adoption of oral medications, have increased demand nasal spray across regions.

Based on research studies and ongoing trials, effective medication for allergies and depression has exhibited the ability to support patients in achieving their clinical goals. Such factors are expected to create opportunities for the expansion of the nasal spray market size over the forecast period, which is projected to expand at a CAGR of more than 6% over 2020-2030.

What is the Impact of Market Consolidation on Nasal Spray Sales?

Given the consolidation in the market, key players are focusing on mergers and acquisitions to explore lucrative opportunities. Leading manufacturers are focusing on improving their commercializing efforts following regulatory guidelines. These trends are being actively followed throughout North America, Latin America, Europe, Asia Pacific, and the Middle East & Africa.

For instance, In June 2019, AptarGroup, Inc. acquired two pharmaceutical services companies, Nanopharm Ltd. and Gateway Analytical LLC, for a combined enterprise value of approximately $50 million. The acquisitions are part of Aptar’s strategy to broaden its portfolio of services that support pharmaceutical and biotech customers to accelerate and derisk their complex product developments.

Additionally, In December 2018, Procter & Gamble (P&G) completed the acquisition of Merck’s Consumer Health business in a €3.4bn ($3.8bn) deal. It is intended to improve P&G’s over the counter (OTC) geographic scale brand portfolio and category footprint across 15 markets.

What are the Hidden Opportunities in Nasal Spray Market?

Opportunities for nasal spray will rise as market players aim at extending their offerings. There is keen focus on improving functionalities in terms of effectiveness and convenience. Also regulatory support to these developments will bode well for the market.

Additionally, along with launching nasal spray, companies are increasing awareness regarding palliative care services. Developing commercial & potential formulations with high efficacy and potency versions are create opportunities for leading companies offering nasal spray.

For instance, in March 2021, the University of Oxford began with the phase-1 clinical trial of a nasal spray formulation of its AstraZeneca-partnered COVID-19 vaccine.

Moreover, nasal sprays are now being used to treat a number of indications apart from allergies and infections. Manufacturers in the market are working towards developing effective nasal sprays for various indications such as depression. Manufacturers in the nasal sprays market are focusing on developing products that can be used as vaccines for prevention of diseases as well.  As intranasal vaccination provides promising non-invasive and gentle alternative. Thus, the nasal spray is expected to offer lucrative opportunities for manufacturers over the coming years.

What are the Driving Factors for Nasal Spray Manufacturers?

Rise in the number of patients, who are suffering from allergic reactions such as cold, congestion, sneezing and runny nose has been fuelling the demand for nasal sprays. While nasal sprays are a popular choice for treating allergic reactions, they can be used for other purposes as well. Studies have shown positive effect of nasal sprays in treating migraines. Moreover, surge in the inclusion of nasal sprays in prescriptions for certain medications after post-operative surgeries are expected to boost consumption of nasal spray as an anti-allergic medicine.

Recently, there has been an increasing emphasis on mental illnesses due to the significant rise in cases with major depressive disorders. Among these, depression is a common mental disorder.

According to the World Health Organization (WHO), more than 264 million people of all ages suffer from depression. Depression is one of the leading contributors to the overall global burden of diseases. Due to the adverse effects of depression, manufacturers in the nasal sprays market are focusing on introducing products that can be used for the treatment in the most effective manner.

For instance, in August 2020, the U.S. Food and Drug Administration (FDA) approved the supplemental new drug application (sNDA) for SPRAVATO® (esketamine) CIII nasal spray developed by the Janssen Pharmaceutical, Inc. SPRAVATO® IS taken with an oral antidepressant, to treat depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior.

Moreover, nasal route holds maximum potential for administration of various drugs with avoidance of first-pass metabolism and the better bioavailability and therapeutic profiles. Thus, nasal route is considered to be the most promising route of drug delivery due the advantages it offers.

Rising awareness about palliative care about mental illness conditions drives the adoption of nasal spray drugs globally. Favorable reimbursement policies and development of innovative products in Europe and North America are boosting the consumption of nasal spray drugs in these regions.

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Country-wise Insights

What Makes the U.S. the Largest Market for Nasal Spray?

The demand for nasal spray is rising in the U.S. due to increasing prevalence of allergies and cases of depression in the country. Branded nasal manufacturers in the U.S. are interested in launching novel products to maintain compliance with updated regulatory guidelines. Moreover, governmental support for ongoing clinical research has allowed the U.S. to dominate the landscape.

Presence of some prominent players such as Johnson & Johnson Services, Inc., Procter & Gamble, Viatris Inc., AdvaCare Pharma, and others has created remarkable scope for the expansion in the country. These companies often rely on product launches to gain competitive edge.

Through the successive development of novel formulations and research studies Janssen Pharmaceutical, Inc., a subsidiary of Johnson & Johnson introduced nasal spray introduced supplemental new drug application (sNDA) for SPRAVATO® (esketamine) CIII nasal spray, taken with an oral antidepressant, to treat depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior.

Why is Demand for Nasal Spray Increasing in the U.K.?

The U.K. healthcare system boasts a well-developed infrastructure, largely funded by the government. It is one of the most successful healthcare systems in the world. It is not surprising that the U.K. has the highest level of spending in Europe. According to the report, the U.K. is identified as a leading market, and the position is likely to remain intact through the forecast period.  

Furthermore, rising research efforts, increasing pipeline drugs, and presence of several major players are creating attractive opportunity for nasal spray market players in the country.

For instance, SaNOtize, alongside Ashford and St Peter’s Hospitals NHS Foundation Trust and Berkshire and Surrey Pathology Services in the UK, have announced results of Phase II trials indicating that SaNOtize’s nasal spray represents a safe and powerful antiviral treatment that could prevent the transmission of Covid-19, shorten its duration, and reduce the severity of symptoms in those already infected.

Why is Innovation Key to Succeed in the German Pharmaceutical Market?

Germany is one of the world’s top most manufacturers of pharmaceuticals. The manufacturers in the country have a competitive advantage as they are developing products and leverage cutting edge research to address the unmet challenges. Additionally, they are constantly investing in order to expand their operations, which is resulting in a more promising pipeline.

Moreover, the companies are prioritizing areas with high unmet needs and working towards developing innovative products in these areas. For instance, in 2020, Bayer AG announced its plan to expand its Beijing supply center with construction of new production and supply facility at Beijing Economic-Technological Development with investment of around US$ 59 million.

What Makes China a Lucrative Market for Nasal spray?

China is the second-leading pharmaceutical market and is rapidly growing based on the two key factors - large-scale capital investment and rapid productivity growth. These two factors make China an attractive destination for foreign investments as well large domestic savings. Since the 1970s, it has been transforming from being a low economic to a more market-oriented country. The market in China accounted for around US$ 2.2 Bn revenue in 2020, and is expected to expand at a CAGR of 6% through 2030.

How Will Increasing Focus on Research Surge Demand for Nasal spray in India?

In recent years, large and small pharmaceutical companies have heavily invested in research operations. Nasal spray demand is likely to grow, as most products in the pipeline, highly due to the pandemic and its improving accessibility and availability. Public-private partnership have become a major business in India due to factors such as presence of government-funded pharmaceutical and medical institutions with advanced facilities, which serves as ideal centers for clinical trials. Moreover, Indian manufacturers are aiming to expand their business through merger and acquisitions with various other companies.

For instance, In April 2019, Cipla Ltd. acquired 30% Stake in South African's Brandmed For Business Expansion. The Acquisition was carried out to pair the company’s strengths with Brandmed’s innovative, patient-centric approach to healthcare which will enhance Cipla Medpro’s portfolio.

Category-wise Insights

Why the Demand for Nasal Steroid is sprays Continuously Rising?

Based on nasal spray products, nasal steroid sprays is leading the market and is Nasal Steroid sprays hold the maximum share in the global sprays market as compared to other product types with a market share of 46%.

Nasal steroid sprays apply a corticosteroid directly into the nose to treat nasal allergy symptoms, such as sneezing and a runny nose. These sprays can provide relief from hay fever or nasal allergies, and can often replace other allergy medications taken orally. A person must use them every day during the allergy season to continue to find relief.

Due to commercialization of cost-effective generics of nasal steroid spray and its convenient availability across Europe countries, the segment is expected to retain its high market share over the forecast period.

Why are aqueous nasal sprays preferred in terms of formulation?

Accounting for more than a third (1/3rd) of overall market share in 2020, aqueous formulation continues to account for bulk use of nasal sprays. They account for the major share, which is attributable to the rapid drug absorption into the mucosal membrane. Moreover, it provides more bioavailability of drug at the site of action. These factors contribute to the rising demand for aqueous nasal formulation.

What advantages of polymer over glass makes it the preferred material?

Polymer will continue accounting for maximum of the global share in terms of materials through the forecast period. According to Future Market Insights, the segment was expected to hold slightly more than 80% of the market share, in terms of material, in the year 2021. The major benefit of polymer over glass is that polymer is less expensiveness. Also, it poses less or no risk of breakage of the container.

Why does the pump bottles hold maximum share in the market?

Pump bottles held maximum share of about 75% among all packaging and is expected hold dominance through the forecast period. The main reason driving the growth in the segment is the dose accuracy provided by the pump bottles. Moreover, it can also be used for solutions with high viscosity for which pressurized sprays are difficult to use. Also, rapid drug delivery is the driving factor for the demand.

Which distribution channel for nasal sprays is highly sought-after?

Institutional sales accounted for around 50% of market among all distribution channels and are expected to grow at an impressive rate over the forecast years. Utilization of recommended nasal sprays in clinics and hospitals, which is often prescribed by a doctor is one of the major factors driving the demand for sales at institutional level. Additionally, the rising prevalence of lung and other pulmonary system diseases increases the demand of the nasal sprays at the hospitals and specialty clinics.

Competitive Landscape

The nasal spray market is greatly consolidated in nature, with the presence of leading players operating in this space. They are focusing on research & development activities primarily to offer treatment for allergic reactions and other therapeutic applications such as cough suppression and running nose suppression in various clinical and research fields. With this, market players are also engaged in expanding their global and regional presence through acquisitions, expansions, product launches, and improvement of distribution channels.

• For Instance, in 2019, Bayer Consumer Health entered into a partnership with DKSH Cambodia, a leading market expansion services provider for companies seeking to grow their business in Asia. The partnership was carried out with an aim to bring Bayer’s over-the –counter products to pharmacies, clinics and hospitals across Cambodia.

Nasal spray manufacturers with patented drugs are successfully allocating their distribution rights to local companies that are operational in the pain management business. This strategy provides momentum to the growth of these companies’ business, owing to strong demand for generic drugs.

For instance, In November 2019, Sandoz announced that it has entered into a binding agreement for the planned acquisition of the Japanese business of Aspen Global Incorporated (AGI), a wholly owned subsidiary of Aspen Pharmacare Holdings Limited. Strengthening position in world’s third largest generics market.

Some of the leading companies operating in the market are:

• Astra Zeneca  Plc.
• Cipla Ltd.
• Johnson & Johnson Services, Inc. (Johnson & Johnson Pacific Pty Limited)
• Glaxosmithkline Plc.
• Novartis International AG
• Procter & Gamble
• Sanofi S.A. (Sanofi-aventis LLC.)
• Boehringer Ingelheim GmbH
• AdvaCare Pharma
• Bayer AG (Bayer Consumer Health
• Covis Pharma S.a.r.l.
• Nipro Corporation (NIPRO JMI Pharma Ltd.)
• Viatris Inc. (Meda Pharmaceuticals Inc.)
• Perrigo Company plc
• AptarGroup, Inc.
• Berry Global, Inc.
• URSATEC GmbH
• Gerresheimer AG
• Bona
• Avantor, VWR International, LLC
• Spectrum Laboratory Products, Inc.  (Spectrum Pharmacy Products)
• SKS Bottle & Packaging, Inc.
• Coster Tecnologie Speciali S.p.A

*The list is not exhaustive, and only for representational purposes. Full competitive intelligence available in the report.

Scope of Report

Key Questions Answered in Report

• What is nasal spray market size?

  The global nasal spray market is forecast to exhibit impressive growth to reach US$ 27.37 Bn by 2030.

• Which is the highly sought-after nasal spray type?

  Based on products, nasal steroid sprays is leading the market and is expected to account for 46% of sales registered.

• Which is the preferred nasal spray formulation?

  Aqueous formulation accounted for the highest share in the market.

• Which are the leading companies in the nasal spray landscape?

  Some of the prominent companies offering nasal spray include Astra Zeneca  Plc. Cipla Ltd., Johnson & Johnson Services, Inc. (Johnson & Johnson Pacific Pty Limited), Glaxosmithkline Plc., Novartis International AG, Procter & Gamble, Sanofi S.A. (Sanofi-aventis LLC.), Boehringer Ingelheim GmbH, AdvaCare Pharma, Bayer AG (Bayer Consumer Health, Covis Pharma S.a.r.l., Nipro Corporation (NIPRO JMI Pharma Ltd.), Viatris Inc. (Meda Pharmaceuticals Inc.), Perrigo Company plc, AptarGroup, Inc., Berry Global, Inc., URSATEC GmbH, Gerresheimer AG, Bona, Avantor, VWR International, LLC, Spectrum Laboratory Products, Inc.  (Spectrum Pharmacy Products), SKS Bottle & Packaging, Inc., Coster Tecnologie Speciali S.p.A

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Market by Category

Product

• Decongestant Sprays
• Nasal Steroid Sprays
• Nasal Antihistamine Sprays
• Nasal Cromolyn Sodium Sprays
• Nasal Anticholinergic Sprays
• Nasal Triamcinolone Sprays

Formulation

• Aqueous
• Hydroalcoholic
• Nonaqueous-Based Solution
• Suspension
• Emulsions
• Dry Powder/Micro particles

Packaging

• Pressurized Canisters
• Pump Bottles 

 Distribution Channel

• Institutional Sales
  • Hospitals
  • Community Clinics
  • Specialty Clinics
  • Public Health Agencies
  • Veterinary Hospitals & Clinics
• Retail Sales
  • Retail Pharmacies
  • Drug Stores
  • Mail Order Pharmacy

Region

• North America
• Latin America
• Europe
• South Asia
• East Asia
• Oceania
• MEA